IJMS, Vol. 25, Pages 4378: Molecular Mechanisms Responsible for the Therapeutic Potential of Mesenchymal Stem Cell-Derived Exosomes in the Treatment of Lung Fibrosis International Journal of Molecular Sciences doi: 10.3390/ijms25084378 Authors: Carl Randall Harrell Valentin Djonov Ana Volarevic Aleksandar Arsenijevic Vladislav Volarevic Mesenchymal stem cell-derived exosomes (MSC-Exos) are nano-sized extracellular vesicles which contain various MSC-sourced anti-fibrotic, immunoregulatory and angio-modulatory proteins (growth factors, immunoregulatory cytokines, chemokines), lipids, and nucleic ..read more

IJMS, Vol. 25, Pages 4395: Novel Concept of Alpha Satellite Cascading Higher-Order Repeats (HORs) and Precise Identification of 15mer and 20mer Cascading HORs in Complete T2T-CHM13 Assembly of Human Chromosome 15 International Journal of Molecular Sciences doi: 10.3390/ijms25084395 Authors: Matko Glunčić Ines Vlahović Marija Rosandić Vladimir Paar Unraveling the intricate centromere structure of human chromosomes holds profound implications, illuminating fundamental genetic mechanisms and potentially advancing our comprehension of genetic disorders and therapeutic interventions. This study rig ..read more

IJMS, Vol. 25, Pages 4373: Eosinophils in Oral Disease: A Narrative Review International Journal of Molecular Sciences doi: 10.3390/ijms25084373 Authors: Huda Moutaz Asmael Al-Azzawi Rita Paolini Nicola Cirillo Lorraine Ann O’Reilly Ilaria Mormile Caroline Moore Tami Yap Antonio Celentano The prevalence of diseases characterised by eosinophilia is on the rise, emphasising the importance of understanding the role of eosinophils in these conditions. Eosinophils are a subset of granulocytes that contribute to the body’s defence against bacterial, viral, and parasitic infections, but ..read more

IJMS, Vol. 25, Pages 4423: The Anticancer Activities of Natural Terpenoids That Inhibit Both Melanoma and Non-Melanoma Skin Cancers International Journal of Molecular Sciences doi: 10.3390/ijms25084423 Authors: Ye Eun Yoon Young Jae Jung Sung-Joon Lee The prevalence of two major types of skin cancer, melanoma and non-melanoma skin cancer, has been increasing worldwide. Skin cancer incidence is estimated to rise continuously over the next 20 years due to ozone depletion and an increased life expectancy. Chemotherapeutic agents could affect healthy cells, and thus may be toxic to them and cause ..read more

IJMS, Vol. 25, Pages 4391: Chemical Modifications to Enhance the Drug Properties of a VIP Receptor Antagonist (ANT) Peptide International Journal of Molecular Sciences doi: 10.3390/ijms25084391 Authors: Christina Lester Jian-Ming Li Tenzin Passang Yuou Wang Edmund K. Waller Simon B. Blakey Antagonist peptides (ANTs) of vasoactive intestinal polypeptide receptors (VIP-Rs) are shown to enhance T cell activation and proliferation in vitro, as well as improving T cell-dependent anti-tumor response in acute myeloid leukemia (AML) murine models. However, peptide therapeutics often suffer from poor m ..read more

IJMS, Vol. 25, Pages 4419: Development of an Innovative Biosensor Based on Graphene/PEDOT/Tyrosinase for the Detection of Phenolic Compounds in River Waters International Journal of Molecular Sciences doi: 10.3390/ijms25084419 Authors: Alexandra Virginia Bounegru Catalina Iticescu Lucian P. Georgescu Constantin Apetrei Phenolic compounds, originating from industrial, agricultural, and urban sources, can leach into flowing waters, adversely affecting aquatic life, biodiversity, and compromising the quality of drinking water, posing potential health hazards to humans. Thus, monitoring and mitiga ..read more

IJMS, Vol. 25, Pages 4396: Novel Amidine Derivative K1586 Sensitizes Colorectal Cancer Cells to Ionizing Radiation by Inducing Chk1 Instability International Journal of Molecular Sciences doi: 10.3390/ijms25084396 Authors: Hang Soo Kim Ji-Eun Park Won Hyung Lee Young Bin Kwon Young-Bae Seu Kwang Seok Kim Checkpoint kinase 1 (Chk1) is a key mediator of the DNA damage response that regulates cell cycle progression, DNA damage repair, and DNA replication. Small-molecule Chk1 inhibitors sensitize cancer cells to genotoxic agents and have shown preclinical activity as single agents in cancers chara ..read more

IJMS, Vol. 25, Pages 4408: Zinc Finger-Homeodomain Transcriptional Factors (ZHDs) in Cucumber (Cucumis sativus L.): Identification, Evolution, Expression Profiles, and Function under Abiotic Stresses International Journal of Molecular Sciences doi: 10.3390/ijms25084408 Authors: Yiming Gao Liyan Zhu Menghang An Yaru Wang Sen Li Yuming Dong Songlin Yang Kexin Shi Shanshan Fan Xiaofeng Chen Huazhong Ren Xingwang Liu Cucumber (Cucumis sativus L.) is a globally prevalent and extensively cultivated vegetable whose yield is significantly influenced by various abiotic stresses, including drought, heat ..read more

IJMS, Vol. 25, Pages 4376: The Inhibition of NS2B/NS3 Protease: A New Therapeutic Opportunity to Treat Dengue and Zika Virus Infection International Journal of Molecular Sciences doi: 10.3390/ijms25084376 Authors: Josè Starvaggi Santo Previti Maria Zappalà Roberta Ettari In the global pandemic scenario, dengue and zika viruses (DENV and ZIKV, respectively), both mosquito-borne members of the flaviviridae family, represent a serious health problem, and considering the absence of specific antiviral drugs and available vaccines, there is a dire need to identify new targets to treat these types of ..read more

IJMS, Vol. 25, Pages 4405: Role of Epiregulin on Lipopolysaccharide-Induced Hepatocarcinogenesis as a Mediator via EGFR Signaling in the Cancer Microenvironment International Journal of Molecular Sciences doi: 10.3390/ijms25084405 Authors: Takahiro Kubo Norihisa Nishimura Kosuke Kaji Fumimasa Tomooka Akihiko Shibamoto Satoshi Iwai Junya Suzuki Hideto Kawaratani Tadashi Namisaki Takemi Akahane Hitoshi Yoshiji Lipopolysaccharides (LPSs) have been reported to be important factors in promoting the progression of hepatocellular carcinoma (HCC), but the corresponding molecular mechanisms remain to b ..read more