Correction: Searching across-cohort relatives in 54,092 GWAS samples via encrypted genotype regression
PLOS Genetics
by The PLOS Genetics Staff
4d ago
by The PLOS Genetics Staff ..read more
Visit website
IntroUNET: Identifying introgressed alleles via semantic segmentation
PLOS Genetics
by Dylan D. Ray, Lex Flagel, Daniel R. Schrider
4d ago
by Dylan D. Ray, Lex Flagel, Daniel R. Schrider A growing body of evidence suggests that gene flow between closely related species is a widespread phenomenon. Alleles that introgress from one species into a close relative are typically neutral or deleterious, but sometimes confer a significant fitness advantage. Given the potential relevance to speciation and adaptation, numerous methods have therefore been devised to identify regions of the genome that have experienced introgression. Recently, supervised machine learning approaches have been shown to be highly effective for detecting introgre ..read more
Visit website
TRPS1 modulates chromatin accessibility to regulate estrogen receptor alpha (ER) binding and ER target gene expression in luminal breast cancer cells
PLOS Genetics
by Thomas G. Scott, Kizhakke Mattada Sathyan, Daniel Gioeli, Michael J. Guertin
4d ago
by Thomas G. Scott, Kizhakke Mattada Sathyan, Daniel Gioeli, Michael J. Guertin Common genetic variants in the repressive GATA-family transcription factor (TF) TRPS1 locus are associated with breast cancer risk, and luminal breast cancer cell lines are particularly sensitive to TRPS1 knockout. We introduced an inducible degron tag into the native TRPS1 locus within a luminal breast cancer cell line to identify the direct targets of TRPS1 and determine how TRPS1 mechanistically regulates gene expression. We acutely deplete over 80 percent of TRPS1 from chromatin within 30 minutes of inducing de ..read more
Visit website
Dual mutations in the whitefly nicotinic acetylcholine receptor β1 subunit confer target-site resistance to multiple neonicotinoid insecticides
PLOS Genetics
by Cheng Yin, Andrias O. O’Reilly, Shao-Nan Liu, Tian-Hua Du, Pei-Pan Gong, Cheng-Jia Zhang, Xue-Gao Wei, Jing Yang, Ming-Jiao Huang, Bu-Li Fu, Jin-Jin Liang, Hu Xue, Jin-Yu Hu, Yao Ji, Chao He, He Du, Chao Wang, Rong Zhang, Qi-Mei Tan, Han-Tang Lu, Wen Xie, Dong Chu, Xu-Guo Zhou, Ralf Nauen, Lian-You Gui, Chris Bass, Xin Yang, You-Jun Zhang
4d ago
by Cheng Yin, Andrias O. O’Reilly, Shao-Nan Liu, Tian-Hua Du, Pei-Pan Gong, Cheng-Jia Zhang, Xue-Gao Wei, Jing Yang, Ming-Jiao Huang, Bu-Li Fu, Jin-Jin Liang, Hu Xue, Jin-Yu Hu, Yao Ji, Chao He, He Du, Chao Wang, Rong Zhang, Qi-Mei Tan, Han-Tang Lu, Wen Xie, Dong Chu, Xu-Guo Zhou, Ralf Nauen, Lian-You Gui, Chris Bass, Xin Yang, You-Jun Zhang Neonicotinoid insecticides, which target insect nicotinic acetylcholine receptors (nAChRs), have been widely and intensively used to control the whitefly, Bemisia tabaci, a highly damaging, globally distributed, crop pest. This has inevitably led to the em ..read more
Visit website
Gametic selection favours polyandry and selfing
PLOS Genetics
by Michael Francis Scott, Carl Mackintosh, Simone Immler
1w ago
by Michael Francis Scott, Carl Mackintosh, Simone Immler Competition among pollen or sperm (gametic selection) can cause evolution. Mating systems shape the intensity of gametic selection by determining the competitors involved, which can in turn cause the mating system itself to evolve. We model the bidirectional relationship between gametic selection and mating systems, focusing on variation in female mating frequency (monandry-polyandry) and self-fertilisation (selfing-outcrossing). First, we find that monandry and selfing both reduce the efficiency of gametic selection in removing deleteri ..read more
Visit website
CryptoCEN: A Co-Expression Network for Cryptococcus neoformans reveals novel proteins involved in DNA damage repair
PLOS Genetics
by Matthew J. O’Meara, Jackson R. Rapala, Connie B. Nichols, A. Christina Alexandre, R. Blake Billmyre, Jacob L Steenwyk, J. Andrew Alspaugh, Teresa R. O’Meara
1w ago
by Matthew J. O’Meara, Jackson R. Rapala, Connie B. Nichols, A. Christina Alexandre, R. Blake Billmyre, Jacob L Steenwyk, J. Andrew Alspaugh, Teresa R. O’Meara Elucidating gene function is a major goal in biology, especially among non-model organisms. However, doing so is complicated by the fact that molecular conservation does not always mirror functional conservation, and that complex relationships among genes are responsible for encoding pathways and higher-order biological processes. Co-expression, a promising approach for predicting gene function, relies on the general principal that gene ..read more
Visit website
Het-B allorecognition in Podospora anserina is determined by pseudo-allelic interaction of genes encoding a HET and lectin fold domain protein and a PII-like protein
PLOS Genetics
by Corinne Clavé, Sonia Dheur, Sandra Lorena Ament-Velásquez, Alexandra Granger-Farbos, Sven J. Saupe
1w ago
by Corinne Clavé, Sonia Dheur, Sandra Lorena Ament-Velásquez, Alexandra Granger-Farbos, Sven J. Saupe Filamentous fungi display allorecognition genes that trigger regulated cell death (RCD) when strains of unlike genotype fuse. Podospora anserina is one of several model species for the study of this allorecognition process termed heterokaryon or vegetative incompatibility. Incompatibility restricts transmission of mycoviruses between isolates. In P. anserina, genetic analyses have identified nine incompatibility loci, termed het loci. Here we set out to clone the genes controlling het-B incomp ..read more
Visit website
High germline mutation rates, but not extreme population outbreaks, influence genetic diversity in a keystone coral predator
PLOS Genetics
by Iva Popovic, Lucie A. Bergeron, Yves-Marie Bozec, Ann-Marie Waldvogel, Samantha M. Howitt, Katarina Damjanovic, Frances Patel, Maria G. Cabrera, Gert Wörheide, Sven Uthicke, Cynthia Riginos
1w ago
by Iva Popovic, Lucie A. Bergeron, Yves-Marie Bozec, Ann-Marie Waldvogel, Samantha M. Howitt, Katarina Damjanovic, Frances Patel, Maria G. Cabrera, Gert Wörheide, Sven Uthicke, Cynthia Riginos Lewontin’s paradox, the observation that levels of genetic diversity (π) do not scale linearly with census population size (Nc) variation, is an evolutionary conundrum. The most extreme mismatches between π and Nc are found for highly abundant marine invertebrates. Yet, the influences of new mutations on π relative to extrinsic processes such as Nc fluctuations are unknown. Here, we provide the first ger ..read more
Visit website
Nazo, the Drosophila homolog of the NBIA-mutated protein–c19orf12, is required for triglyceride homeostasis
PLOS Genetics
by Perinthottathil Sreejith, Sara Lolo, Kristen R. Patten, Maduka Gunasinghe, Neya More, Leo J. Pallanck, Rajnish Bharadwaj
2w ago
by Perinthottathil Sreejith, Sara Lolo, Kristen R. Patten, Maduka Gunasinghe, Neya More, Leo J. Pallanck, Rajnish Bharadwaj Lipid dyshomeostasis has been implicated in a variety of diseases ranging from obesity to neurodegenerative disorders such as Neurodegeneration with Brain Iron Accumulation (NBIA). Here, we uncover the physiological role of Nazo, the Drosophila melanogaster homolog of the NBIA-mutated protein–c19orf12, whose function has been elusive. Ablation of Drosophila c19orf12 homologs leads to dysregulation of multiple lipid metabolism genes. nazo mutants exhibit markedly reduced g ..read more
Visit website
Estimating the health impact of nicotine exposure by dissecting the effects of nicotine versus non-nicotine constituents of tobacco smoke: A multivariable Mendelian randomisation study
PLOS Genetics
by Jasmine N. Khouja, Eleanor Sanderson, Robyn E. Wootton, Amy E. Taylor, Billy A. Church, Rebecca C. Richmond, Marcus R. Munafò
2w ago
by Jasmine N. Khouja, Eleanor Sanderson, Robyn E. Wootton, Amy E. Taylor, Billy A. Church, Rebecca C. Richmond, Marcus R. Munafò The detrimental health effects of smoking are well-known, but the impact of regular nicotine use without exposure to the other constituents of tobacco is less clear. Given the increasing daily use of alternative nicotine delivery systems, such as e-cigarettes, it is increasingly important to understand and separate the effects of nicotine use from the impact of tobacco smoke exposure. Using a multivariable Mendelian randomisation framework, we explored the direct eff ..read more
Visit website

Follow PLOS Genetics on FeedSpot

Continue with Google
Continue with Apple
OR