Researchers at Children's Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania have revealed a powerful new bone marrow atlas that will offer the public a first-of-its-kind visual passport into the spectrum of healthy and diseased blood production. The findings are published in the journal Cell ..read more

Researchers from the UAB have identified a region in the early aggregates of the alpha-synuclein protein that can be targeted to prevent its conversion into the toxic amyloid fibrils that accumulate in the brains of people suffering from Parkinson's disease ..read more

Researchers from the Research Area on Neurological Diseases, Neuroscience, and Mental Health at the Sant Pau Research Institute, led by Dr. Juan Fortea, Director of the Memory Unit of the Neurology Service at the same hospital, have found that over 95% of individuals over 65 years old who have two copies of the APOE4 gene—APOE4 homozygotes—show biological characteristics of Alzheimer's pathology in the brain or biomarkers of this disease in cerebrospinal fluid and PET scans ..read more

By the time cancer is diagnosed, a lot has already happened behind the scenes. Although cancers are classed into early and late stages for clinical purposes, even an "early" stage tumor is the result of many previous, undetectable cellular and molecular changes in the body ..read more

The journey of cancer genomic medicine (CGM) began in the 1980s, with the discovery of various genomic and epigenomic alterations in cancer cells from various countries including Japan. This led to the development of molecular targeted therapies in the 2000s ..read more

Behavioral similarities between parents and their offspring are less marked than is often suggested, a new study shows ..read more

Working with human breast and lung cells, Johns Hopkins Medicine scientists say they have charted a molecular pathway that can lure cells down a hazardous path of duplicating their genome too many times, a hallmark of cancer cells ..read more

For most patients, it's unknown exactly what causes amyotrophic lateral sclerosis (ALS), a disease characterized by degeneration of motor neurons that impairs muscle control and eventually leads to death ..read more

The length of telomeres in white blood cells, known as leukocytes, varies significantly among sub-Saharan African populations, researchers report in The American Journal of Human Genetics. Moreover, leukocyte telomere length (LTL) is negatively associated with malaria endemicity and only partly explained by genetic factors ..read more

Genetics can be associated with one's behavior and health—from the willingness to take risks, and how long one stays in school, to chances of developing Alzheimer's disease and breast cancer. Although our fate is surely not written in our genes, corporations may still find genetic data valuable for risk assessment and business profits, according to a perspective published in The American Journal of Human Genetics. The researchers stress the need for policy safeguards to address ethics and policy concerns regarding collecting genetic data ..read more