An enzymatic cocktail can kill a variety of mycobacterial species of bacteria, including those that cause tuberculosis ..read more

A study has identified a combination of medications that may improve blood flow within granulomas, benefiting drug delivery. The study leverages decades of cancer research to study tuberculosis-affected lung tissue and improve treatment ..read more

Millions of people are spreading tuberculosis unknowingly - now scientists say they are close to developing a new test that is as simple as the lateral flows used during the Covid pandemic ..read more

Scientists have uncovered important clues to how human T cells combat Mycobacterium tuberculosis, the bacterium that causes TB ..read more

Tuberculosis, caused by the bacterium Mycobacterium tuberculosis (Mtb) kills upwards of 1.6 million people a year, making it one of the leading causes of death by an infectious agent worldwide -- and that number is only growing larger. How, exactly, Mtb evades the immune system isn't yet known, but a collaborative team of researchers recently discovered something surprising: prior exposure to a genus of bacteria called Mycobacterium seems to remodel the first-line defenders in the body's immune system ..read more

Tuberculosis (TB) is the leading infectious killer worldwide, with 10.6 million cases and 1.6 million deaths in 2021 alone. One in five incident TB cases were attributable to malnutrition, more than double the number attributed to HIV/AIDS. Like HIV/AIDS, malnutrition is a cause of secondary immunodeficiency, known as nutritionally acquired immunodeficiency syndrome (N-AIDS). However, N-AIDS remains the neglected cousin of HIV/AIDS in global TB elimination efforts. In a review paper, researchers reviewed decades of data and make the case that N-AIDS, just like HIV/AIDS, also deserves special c ..read more

A research team has detected various substances that have a dual effect against tuberculosis: They make the bacteria causing the disease less pathogenic for human immune cells and boost the activity of conventional antibiotics ..read more

Medical researchers are striving to fast-track the development of innovative Tuberculosis (TB) treatments. They have announced the start of a phase 2B/C clinical trial program. The announcement is a major milestone for the project and the TB community as a whole, helping to advance TB science and enhance the efficiency with which new treatments are delivered ..read more

The ability of Mycobacterium tuberculosis (MTB), a serious respiratory infection, to form snake-like cords was first noted nearly 80 years ago. Investigators report the biophysical mechanisms by which these cords form and demonstrate how several generations of dividing bacteria hang together to create these structures that enable resistance to antibiotics ..read more

Scientists have discovered a tuberculosis (TB) vaccination strategy that could prevent the leading cause of death among people worldwide living with HIV. The results showed that, when given intravenously, the only commercially available vaccine against TB successfully and safely prevents lung infection in monkeys infected with the simian, or primate, form of HIV, called SIV. This is despite the vaccine being contraindicated for people living with HIV ..read more