Expression of hormone receptors is associated with specific immunological profiles of the breast cancer microenvironment
Breast Cancer Research
by Toru Hanamura, Shigehisa Kitano, Hiroshi Kagamu, Makiko Yamashita, Mayako Terao, Takuho Okamura, Nobue Kumaki, Katsuto Hozumi, Takayuki Iwamoto, Chikako Honda, Sasagu Kurozumi and Naoki Niikura
4d ago
Elucidating the unique immunoregulatory mechanisms in breast cancer microenvironment may help develop new therapeutic strategies. Some studies have suggested that hormone receptors also have immune regulatory ..read more
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Correction: Multimorbidity and overall survival among women with breast cancer: results from the South African Breast Cancer and HIV Outcomes Study
Breast Cancer Research
by Oluwatosin A. Ayeni, Maureen Jofe, Witness Mapanga, Wenlong Carl Chen, Daniel S. O’Neil, Boitumelo Phakathi, Sarah Nietz, Ines Buccimazza, Sharon Čačala, Laura W. Stopforth, Judith S. Jacobson, Katherine D. Crew, Alfred I. Neugut, Duvern Ramiah, Paul Ruf, Herbert Cubasch…
4d ago
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Changes in the tumor oxygenation but not in the tumor volume and tumor vascularization reflect early response of breast cancer to neoadjuvant chemotherapy
Breast Cancer Research
by Mikhail V. Pavlov, Anna P. Bavrina, Vladimir I. Plekhanov, German Yu. Golubyatnikov, Anna G. Orlova, Pavel V. Subochev, Diana A. Davydova, Ilya V. Turchin and Anna V. Maslennikova
4d ago
Breast cancer neoadjuvant chemotherapy (NACT) allows for assessing tumor sensitivity to systemic treatment, planning adjuvant treatment and follow-up. However, a sufficiently large number of patients fail to a ..read more
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Transcriptomic alterations underlying metaplasia into specific metaplastic components in metaplastic breast carcinoma
Breast Cancer Research
by Huang-Chun Lien, Chia-Lang Hsu, Yen-Shen Lu, Tom Wei-Wu Chen, I.-Chun Chen, Yu-Chia Li, Chiun-Sheng Huang, Ann-Lii Cheng and Ching-Hung Lin
1w ago
Metaplastic breast carcinoma (MpBC) typically consists of carcinoma of no special type (NST) with various metaplastic components. Although previous transcriptomic and proteomic studies have reported subtype-re ..read more
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Tumor necroptosis-mediated shedding of cell surface proteins promotes metastasis of breast cancer by suppressing anti-tumor immunity
Breast Cancer Research
by Zhaoshan Liu, Swati Choksi, Hyung-Joon Kwon, Delong Jiao, Chengyu Liu and Zheng-gang Liu
1w ago
Necroptosis is a form of regulated necrosis and is executed by MLKL when MLKL is engaged in triggering the rupture of cell plasma membrane. MLKL activation also leads to the protease, ADAMs-mediated ectodomain ..read more
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Association between human blood metabolome and the risk of breast cancer
Breast Cancer Research
by Yu Wang, Fanghua Liu, Lulu Sun, Yiming Jia, Pinni Yang, Daoxia Guo, Mengyao Shi, Aili Wang, Guo-Chong Chen, Yonghong Zhang and Zhengbao Zhu
1w ago
Breast cancer is the most common cancer among women with limited treatment options. To identify promising drug targets for breast cancer, we conducted a systematical Mendelian randomization (MR) study to scree ..read more
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Multimorbidity and overall survival among women with breast cancer: results from the South African Breast Cancer and HIV Outcomes Study
Breast Cancer Research
by Oluwatosin A. Ayeni, Maureen Joffe, Witness Mapanga, Wenlong Carl Chen, Daniel S. O’Neil, Boitumelo Phakathi, Sarah Nietz, Ines Buccimazza, Sharon Čačala, Laura W. Stopforth, Judith S. Jacobson, Katherine D. Crew, Alfred I. Neugut, Duvern Ramiah, Paul Ruff, Herbert Cubasch…
1w ago
Breast cancer survival in South Africa is low, but when diagnosed with breast cancer, many women in South Africa also have other chronic conditions. We investigated the impact of multimorbidity (≥ 2 other chro ..read more
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Sustained postconfluent culture of human mammary epithelial cells enriches for luminal and c-Kit+ subtypes
Breast Cancer Research
by Michael E. Todhunter, Masaru Miyano, Eric G. Carlson, Stefan Hinz and Mark A. LaBarge
2w ago
A challenge in human mammary epithelial cell (HMEC) culture is sustaining the representation of competing luminal, myoepithelial, and progenitor lineages over time. As cells replicate in culture, myoepithelial ..read more
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A prospective case–cohort analysis of plasma metabolites and breast cancer risk
Breast Cancer Research
by Victoria L. Stevens, Brian D. Carter, Eric J. Jacobs, Marjorie L. McCullough, Lauren R. Teras and Ying Wang
2w ago
Breast cancer incidence rates have not declined despite an improvement in risk prediction and the identification of modifiable risk factors, suggesting the need to identify novel risk factors and etiological p ..read more
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MTX-PEG-modified CG/DMMA polymeric micelles for targeted delivery of doxorubicin to induce synergistic autophagic death against triple-negative breast cancer
Breast Cancer Research
by Zhiwen Cao, Rui Liu, Yang Li, Xinyi Luo, Zhenglai Hua, Xiangpeng Wang, Zeyu Xue, Zhengjia Zhang, Cheng Lu, Aiping Lu and Yuanyan Liu
3w ago
The chemotherapy of triple-negative breast cancer based on doxorubicin (DOX) regimens suffers from great challenges on toxicity and autophagy raised off-target. In this study, a conjugate methotrexate-polyethy ..read more
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