Elenagen delays disease progression
Oncology News Australia » Ovarian Cancer
by ONA Editor
1d ago
CureLab Oncology, a clinical-stage, pre-IPO biotech company, announced that its novel biological agent, Elenagen, has been shown to significantly enhance standard chemotherapy and provides clinical benefits for the patients with the deadliest form ovarian cancer. Elenagen belongs to a novel class of biological agents, supercoiled circular DNA (plasmids). The study, published in Frontiers in Oncology, shows that ..read more
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Outsmarting chemo-resistant ovarian cancer
Oncology News Australia » Ovarian Cancer
by ONA Editor
1d ago
Women diagnosed with ovarian cancer may initially respond well to chemotherapy, but the majority of them will develop resistance to treatment and die from the disease. Now Northwestern Medicine scientists have discovered the Achilles heel of chemotherapy-resistant ovarian cancer — its hunger for cholesterol — and how to sneakily use that to destroy it. In ..read more
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Researchers leverage AI to develop early diagnostic test for ovarian cancer
Oncology News Australia » Ovarian Cancer
by ONA Editor
3w ago
For over three decades, a highly accurate early diagnostic test for ovarian cancer has eluded physicians. Now, scientists in the Georgia Tech Integrated Cancer Research Center (ICRC) have combined machine learning with information on blood metabolites to develop a new test able to detect ovarian cancer with 93 percent accuracy among samples from the team’s study group ..read more
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MRNA therapeutic successfully combats ovarian cancer in mice
Oncology News Australia » Ovarian Cancer
by ONA Editor
1M ago
Each year, several thousand women in Germany die from ovarian cancer. In many cases, the disease is only detected when it is very advanced and metastases have already formed – usually in the intestines, abdomen or lymph nodes. At such a late stage, only 20 to 30 percent of all those affected survive the next ..read more
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Ageing in cells may boost ovarian cancer spread
Oncology News Australia » Ovarian Cancer
by ONA Editor
1M ago
Ovarian cancer is dangerous because it often goes undetected until it has spread beyond the ovaries, and the symptoms can also be attributed to other conditions. Scientists believe that ageing can increase the spread of ovarian and other cancers, but the underlying mechanisms are not fully clear. Now, researchers at the Indian Institute of Science (IISc) have found that ..read more
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“Big data” analysis reveals new targets for treating ovarian cancer
Oncology News Australia » Ovarian Cancer
by ONA Editor
1M ago
A recent study led by Hidenori Machino at the RIKEN Center for Advanced Intelligence Project (AIP) and the National Cancer Center Research Institute in Japan used a big data multi-omics analysis to examine changes in gene expression as cells from human fallopian tubes become cancerous. After identifying dysregulation in several biological signalling pathways, they were ..read more
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One more step towards treatment of PARP inhibitor-resistant ovarian cancers
Oncology News Australia » Ovarian Cancer
by ONA Editor
1M ago
A new editorial paper was published in Oncotarget‘s Volume 14 on December 22, 2023, entitled, “One more step toward treatment of PARP inhibitor-resistant ovarian cancers.” LISTEN NOW ON THE ONCOLOGY NETWORK Over 80% of ovarian cancer cases experience recurrence, resulting in roughly 12,000 annual deaths in the United States. While targeted therapies like poly (ADPribose) polymerase inhibitors (PARPis ..read more
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New Peter Mac study shows innovative drug can stop cancer growth
Oncology News Australia » Ovarian Cancer
by ONA Editor
1M ago
A new Peter Mac study using a pioneering drug has successfully controlled the growth of tumours and overcome existing drug resistance in multiple cancer types. An enzyme critically associated with tumour growth, called cyclin-dependent kinase 2 (CDK2), has long been a target for researchers but it has been incredibly difficult to create a therapeutic drug ..read more
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Study reports progress in long-term protection against ovarian cancer tumours
Oncology News Australia » Ovarian Cancer
by ONA Editor
2M ago
Investigators from the C.S. Mott Center for Human Growth and Development at the Wayne State University School of Medicine reported today in a publication in Cancer Immunology Research the characterisation of a novel therapeutic approach capable of restoring immune surveillance and providing long-term protection against ovarian cancer tumours. The study, “Immune modulation of innate and adaptive responses ..read more
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Ovarian cancer: Artificial intelligence predicts therapy responses
Oncology News Australia » Ovarian Cancer
by ONA Editor
3M ago
A model based on artificial intelligence is able to predict the therapy outcome (measured by volumetric reduction of tumour lesions) in 80% of ovarian cancer patients. The AI-based model has an accuracy of 80%, significantly better than current clinical methods. The tool, named IRON (Integrated Radiogenomics for Ovarian Neoadjuvant therapy), analyses various patient clinical features ..read more
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