Keep Memory Alive raises funds for Lou Ruvo Center for Brain Health
Parkinson's News Today
by Mary Chapman
3d ago
A host of entertainers and other celebrities turned out for the 27th annual Power of Love gala to celebrate country music star Blake Shelton and support the Cleveland Clinic Lou Ruvo Center for Brain Health. Held at MGM Grand Garden Arena in Las Vegas, the event was presented by Keep Memory Alive, an organization that raises funds through special events and community partnerships for the center at Cleveland Clinic Nevada. Part of the clinic’s philanthropy department, the organization works to raise awareness and funds to fight neurodegenerative diseases such as Parkinson’s disease, amyot ..read more
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Dance for Parkinson’s benefits patients and their relatives: Study
Parkinson's News Today
by Marisa Wexler, MS
3d ago
Participating in a weekly dance class may not only help people with Parkinson’s disease improve their mobility, but also can be an important source of joy that helps patients feel closer to their loved ones. That’s according to a new study from Sweden that investigated the impact of the Dance for Parkinson’s Disease program — begun in the U.S. in 2001 and now available in 28 countries — on various aspects of patients’ lives. Taking part in the dance program led to both physical and emotional benefits for patients and their family members, the researchers found. “Dancers and relatives consiste ..read more
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Early Parkinson’s sleep disorders tied to NfL biomarker in study
Parkinson's News Today
by Lindsey Shapiro, PhD
4d ago
The presence of sleep disorders in the earliest stages of Parkinson’s disease correlated with blood levels of neurofilament light chain (NfL), a biomarker of neurodegeneration, in a study. “This finding underscores the potential of sleep disorders as a robust clinical indicator of neuronal degeneration, closely linked with PD [Parkinson’s disease] progression,” the researchers wrote. The scientists said prompt identification of sleep disorders and NfL monitoring are “pivotal” for enabling early treatment in at-risk patients, and also could be used as biomarkers for evaluating treatment outcom ..read more
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Increasing zinc transporter may be Parkinson’s therapeutic target
Parkinson's News Today
by Andrea Lobo
4d ago
Enhancing mechanisms associated with the degradation of misfolded proteins at the proteasome, that is, cellular structures where these proteins are degraded, may be a new therapeutic target for neurodegenerative diseases, including Parkinson’s disease. That’s according to a new study in fruit flies, where researchers found that the ZIP7 protein, a zinc transporter, was essential for proteasome functioning. When the protein’s levels were increased in a fruit fly model of an eye neurodegenerative disease, misfolded proteins were prevented from accumulating by enhancing proteasome activity, thwa ..read more
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Ali’s daughter takes up the ‘fight’ for Parkinson’s families
Parkinson's News Today
by Mary Chapman
5d ago
Six years before world champion boxer Muhammad Ali was diagnosed with Parkinson’s disease, his young daughter noticed he was slurring his speech. It was around the time of Ali’s heavyweight championship fight against Leon Spinks. “People thought he was ‘punch drunk’ from boxing,” the daughter, Maryum “May May” Ali, recounted in an interview with Parkinson’s News Today. “In 1978, there was nowhere near the information on Parkinson’s as there is now. A lot of people hadn’t heard of it.” At the time, Ali was 36 and the mean age at Parkinson’s onset is typically 60 or older. By then, he had alrea ..read more
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Protein-like polymer may limit oxidative stress, protect nerve cells
Parkinson's News Today
by Andrea Lobo
6d ago
A newly developed molecule showed an ability in lab studies to activate antioxidant responses in brain cells by altering how two proteins, believed to be involved in the development of Parkinson’s disease and other neurodegenerative conditions, interact. The small molecule, known as a protein-like polymer, is designed to bind to target proteins as if it were a protein. Specifically, this protein-like polymer works to block the interaction between Nrf2 and Keap1, proteins involved in the cellular response to oxidative stress — a type of cell damage — within cells of the brain. And it ..read more
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Addressing anxiety may aid walking problems in Parkinson’s
Parkinson's News Today
by Marisa Wexler, MS
6d ago
People with Parkinson’s disease who have clinically significant anxiety tend to walk more slowly and with shorter steps than people with the disease who don’t have anxiety. That’s according to the study, “The impact of anxiety on gait impairments in Parkinson’s disease: insights from sensor-based gait analysis,” which was published in the Journal of NeuroEngineering and Rehabilitation. The changes in walking may make Parkinson’s patients who have anxiety more prone to falls and researchers said the finding suggests that helping patients deal with anxiety may help improve walking ability. “Our ..read more
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Early efficacy data from buntanetap trial delayed, now expected in June
Parkinson's News Today
by Andrea Lobo
1w ago
Topline efficacy data from a Phase 3 clinical trial evaluating the oral therapy buntanetap for early-stage Parkinson’s disease is now expected in June, Annovis Bio, the therapy’s developer, has disclosed. While Annovis originally planned to share its early findings at the beginning of this year, the company faced a delay in the process of data cleaning: Specifically, after unraveling the patients who had received the experimental therapy versus the placebo during the data analysis process, researchers found more blood samples than expected showed no presence of buntanetap. “We were expecting ..read more
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Black phosphorus seen to ease Parkinson’s symptoms in rat model
Parkinson's News Today
by Margarida Maia, PhD
1w ago
Tiny bubbles containing a flaky form of phosphorus, called black phosphorus, delivered to the brain may help to control overactive microglia — the brain’s resident immune cells — that drive the inflammation damaging to nerve cells in Parkinson’s disease, scientists in China report. In a study in a rat model of Parkinson’s, delivering those microbubbles with the aid of low-frequency focused ultrasound waves eased disease symptoms, helping treated rats to swim faster through a water maze and run longer on a rotating rod. These gains, the scientists reported, may come through black phosphor ..read more
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Parkinson’s, cancer tied to dry cleaning site that leaked TCE
Parkinson's News Today
by Margarida Maia, PhD
1w ago
There were more cases of Parkinson’s disease and cancer than expected among attorneys who worked near a now-closed dry cleaner in Rochester, New York that leaked trichloroethylene (TCE) and other dry cleaning solvents into the soil, a study finds. While they failed to reach statistical significance, the findings add to evidence that exposure to chemical hazards in the workplace, at home, and in public places contributes to Parkinson’s. The study, “Dry-Cleaning Chemicals and a Cluster of Parkinson’s Disease and Cancer: A Retrospective Investigation,” was published as a brief report in Movement ..read more
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