Enterprise Therapeutics doses first person with cystic fibrosis in Phase 2 trial for novel therapy ETD001
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7h ago
Enterprise Therapeutics Ltd (Enterprise), a biopharmaceutical company dedicated to the discovery and development of novel therapies to improve the lives of those suffering from respiratory disease, today announced dosing of the first person with cystic fibrosis (pwCF) in its Phase 2a trial of ETD001 ..read more
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Abacavir linked to increased cardiovascular risk in HIV patients, study finds
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7h ago
CJ Fichtenbaum et al. Abacavir is associated with elevated risk for cardiovascular events in the REPRIEVE trial. International AIDS Conference. Friday, July 26, 2024 ..read more
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PrEPVacc HIV vaccine trial shows no reduction in infections
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7h ago
The results of the PrEPVacc HIV vaccine trial conducted in Eastern and Southern Africa, which ran between 2020 and 2024, show conclusively that neither of the two experimental vaccine regimens tested reduced HIV infections among the study population ..read more
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Twincretin drug Tirzepatide shows unmatched efficacy in weight loss and diabetes management
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1w ago
Tirzepatide, a novel twincretin drug, significantly improves weight loss and glycemic control in obese and type 2 diabetes patients, outperforming traditional treatments in clinical trials ..read more
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People of color and white women underrepresented in clinical trials due to systematic biases
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3w ago
Randomized controlled trials, or RCTs, are believed to be the best way to study the safety and efficacy of new treatments in clinical research ..read more
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NIH launches Phase 1 trial for innovative nasal COVID-19 vaccine
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3w ago
A Phase 1 trial testing the safety of an experimental nasal vaccine that may provide enhanced breadth of protection against emerging variants of SARS-CoV-2, the virus that causes COVID-19, is now enrolling healthy adults at three sites in the United States ..read more
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Live biotherapeutic product can improve clinical outcomes for patients with kidney cancer
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3w ago
Physician scientists from City of Hope, one of the largest cancer research and treatment organizations in the United States, found that people with metastatic kidney cancer who orally took a live biotherapeutic product called CBM588 while in treatment with immunotherapy and enzymatic tyrosine kinase inhibitors experienced improved health outcomes ..read more
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Gene therapy milestone at SickKids offers hope for children with SPG50 neurodegenerative disorder
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3w ago
When Michael Pirovolakis received an individualized gene therapy in a single-patient clinical trial at The Hospital for Sick Children (SickKids) in March 2022, the course of his condition was dramatically altered ..read more
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Clinical trial seeks to evaluate safety of new EV-D68 treatment
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3w ago
The National Institutes of Health (NIH) is sponsoring a clinical trial to evaluate the safety of an investigational monoclonal antibody to treat enterovirus D68 (EV-D68), which can cause severe respiratory and neurological diseases such as acute flaccid myelitis (AFM) – similar to polio. Scientists are striving to better understand AFM, which has emerged in the United States with spikes in cases every other year, primarily in the late-summer months over the last decade ..read more
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Assessing clinical benefit and safety in trial waivers for treatment-refractory cancers
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3w ago
Patients with treatment-refractory cancers who received eligibility and testing waivers to participate in a large basket/umbrella oncology trial had similar rates of clinical benefit and adverse events as patients who participated in the trial without waivers ..read more
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