Phase 3 trial shows overall survival benefit from adjuvant therapy in kidney cancer patients
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20h ago
For the first time in fifty years, results from a phase 3 randomized, placebo-controlled trial have shown an overall survival benefit from an adjuvant therapy in patients with kidney cancer ..read more
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Vosoritide's first phase 2 study shows increased growth in children with hypochondroplasia
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5d ago
Vosoritide's first global phase 2 study showed an average increased growth rate of 1.8 cm per year in children with hypochondroplasia, a genetic cause of short stature in children, according to researchers from Children's National Hospital ..read more
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Home-administered nasal spray could be safely used to treat recurrent rapid heart rhythms
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1w ago
A clinical trial led by Weill Cornell Medicine investigators showed that a nasal spray that patients administer at home, without a physician, successfully and safely treated recurrent episodes of a condition that causes rapid abnormal heart rhythms ..read more
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Personalized anti-tumor vaccine enhances immunotherapy for liver cancer
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1w ago
Adding a personalized anti-tumor vaccine to standard immunotherapy is safe and about twice as likely to shrink cancer as standard immunotherapy alone for patients with hepatocellular carcinoma, the most common type of liver cancer, according to a clinical trial led by researchers at the Johns Hopkins Kimmel Cancer Center and its Convergence Institute ..read more
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Ninerafaxstat shows good tolerability and safety in nonobstructive HCM patients
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1w ago
The investigational drug ninerafaxstat showed a good tolerability and safety profile, along with evidence of improvements in symptoms and exercise capacity among people with nonobstructive hypertrophic cardiomyopathy (HCM), according to results of a 12-week phase 2 trial presented at the American College of Cardiology's Annual Scientific Session ..read more
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Investigational drug plozasiran shows promise in reducing severe hypertriglyceridemia
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1w ago
In patients with severely elevated triglyceride levels at risk for developing acute pancreatitis, the investigational drug plozasiran reduced triglyceride levels by an average of 74% after 24 weeks of use without causing any significant safety concerns, according to research presented at the American College of Cardiology's Annual Scientific Session ..read more
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Clinical trial to test the feasibility of using at-home cancer immunotherapy
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2w ago
A clinical trial from Keck Medicine of USC will test the feasibility of treating non-small cell lung cancer with immunotherapy provided at home ..read more
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Minocycline fails to slow vision loss in people with dry age-related macular degeneration
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3w ago
The drug minocycline, an antibiotic that also decreases inflammation, failed to slow vision loss or expansion of geographic atrophy in people with dry age-related macular degeneration (AMD), according to a phase II clinical study at the National Eye Institute (NEI), part of the National Institutes of Health ..read more
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Investigational gene therapy shows promise for rare childhood neurodegenerative disease
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1M ago
An investigational gene therapy for a rare neurodegenerative disease that begins in early childhood, known as giant axonal neuropathy (GAN), was well tolerated and showed signs of therapeutic benefit in a clinical trial led by the National Institutes of Health ..read more
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New treatment approach improves recurrence-free survival in early breast cancer patients
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1M ago
A new treatment approach that combines a targeted therapy drug with hormone therapy significantly increased the amount of time a person with stage 2 or 3 HR-positive, HER2-negative early breast cancer lives without the cancer returning, according to a new study co-led by UCLA Health Jonsson Comprehensive Cancer Center investigators ..read more
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