Beyond Germinal Center B Cells: Developing Memory and Antibody Producing Plasma Cells
Maine Biotechnology
by kimberly
5y ago
I. Overview The primary function of a B cell is to produce antibodies. As we have previously discussed, B cell development is linked to immunoglobulin (antibody) gene rearrangement, and development of (high affinity) antibody specificity is generated through affinity maturation. Affinity maturation takes place in the germinal center and the result of this process is the generation of B cell populations that produce antibodies and memory. In this article, we will explore what happens to activate memory and antibody production following the affinity maturation in the germinal center. II. Review ..read more
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LIVE Webinar: Generating Anti-Idiotype Monoclonal Antibodies
Maine Biotechnology
by kimberly
5y ago
Join us for a LIVE webinar event:  “Custom Antibody Development Approaches for Generating Anti-Idiotype Monoclonal Antibodies for PK Assays”  May 11, 2018 1:00 PM EDT at: https://attendee.gotowebinar.com/register/4964558172351937795 Join Dr. Stephen Pelsue, Science Director at BBI Solutions (formerly Maine Biotechnology Services), in our webinar focused on the development of anti-idiotype (anti-id) antibodies. Anti-id monoclonal antibodies are critical for bioanalytical pharmacokinetic (PK) assays that are required to ensure the safety and efficacy of therapeutic antibody drugs. His presentati ..read more
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View a Sample Antigen Review
Maine Biotechnology
by kimberly
5y ago
Leverage 27 years of immunology and antibody development experience by letting the hybridoma development team at MBS conduct a thorough review of antigen options to meet your project goals. The MBS Antigen Review service can help identify risks and guide the proposal of a successful immunization strategy.  The report generated will include a comparative analysis of: Sequence, Features and Structural Analysis of the Antibody Target Linear Epitope Prediction Homology Analysis Tertiary Structural Analysis of Possible Epitopes A Review of Reagents on the Market and Recommendations for Use Sample ..read more
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BBI Group acquires Maine Biotechnology Services
Maine Biotechnology
by kimberly
5y ago
The BBI Group, partner to the world’s leading diagnostic and healthcare organisations, has entered into a definitive agreement to acquire the Maine Biotechnology Services, Inc. (MBS) located in Portland, Maine (USA). The acquisition of MBS will expand BBI’s portfolio during a period of expansion and growth. The company provides a range of products to the diagnostic, healthcare, research food sectors globally. MBS will add antibody development to its capability and product range. Lyn Rees, CEO of the BBI Group, said: “The acquisition of MBS perfectly complements our current product portfolio an ..read more
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MBS Exhibiting at AAPS National Biotechnology Conference in San Diego, Booth #716
Maine Biotechnology
by kimberly
5y ago
MBS will be attending the AAPS National Biotechnology Conference in San Diego, CA., May 1-3, 2017. Sales and technical teams will be available at booth #716 to answer questions on how MBS custom antibody strategies and services can help you with all your antibody development needs. Stop by and see us. Email us at sales@mainebiotechnology.com to set up a meeting today! The post MBS Exhibiting at AAPS National Biotechnology Conference in San Diego, Booth #716 appeared first on Maine Biotechnology ..read more
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MBS Exhibiting at PEGS in Boston, Booth #100
Maine Biotechnology
by kimberly
5y ago
MBS will be attending the Essential Protein Engineering Summit in Boston, MA., May 1-5, 2017. Sales and technical teams will be available at booth #100 to answer questions on how MBS custom antibody strategies and services can help you with all your antibody development needs. Stop by and see us. Email us at sales@mainebiotechnology.com to request a meeting at PEGS in Boston, May 1-5! The post MBS Exhibiting at PEGS in Boston, Booth #100 appeared first on Maine Biotechnology ..read more
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Immuno-Oncology: Modulating the Immune Response Against Cancer Cells
Maine Biotechnology
by kimberly
5y ago
By: Dr. Stephen Pelsue Overview Neoplasia, or cancer, comes from the Greek meaning “new growth.”  Malignant neoplasms are unrestrained and spread into the surrounding tissue which may lead to physiological impairment.  The “new growth” is a result of genetic changes that limit the effectiveness of normal cell cycle checkpoints and growth parameters.  In many cases, the altered gene expression of the preneoplastic or neoplastic cell can be detected by the immune system through immune surveillance mechanisms which will then target the defective cells and remove them and prevent any harm to the h ..read more
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Some Good News in the Fight Against Cancer
Maine Biotechnology
by kimberly
5y ago
By: Dr. Stephen Pelsue Cancer is caused by the unregulated growth of cells due to genetic alterations. Cancer can be a devastating disease and is seemingly indiscriminate. Due to recent advances in prevention, detection, and treatment; cancer rates have been declining over the last several decades. February is Cancer Prevention Month, so I thought I would highlight a recent report published by the American Cancer Society  (Cancer Statistics, 2016) which has some good news in the fight against cancer. I think the biggest take away from the ACS report is that the overall death rate from cancer h ..read more
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Anti-Drug Antibody Reagent Development
Maine Biotechnology
by kimberly
5y ago
Current industry best practices and FDA guidelines urge therapeutic antibody developers to use affinity-purified polyclonal antibodies in anti-drug assays for immunogenicity studies as well as controls for ongoing drug monitoring. MBS delivers sensitive and specific positive ADA controls through: Dedicated project management of polyclonal antibody development Goal-driven immunization strategies Advanced, application-specific screening of serum samples Custom affinity purification Lifetime supply of antibody generated within 5 months Learn More about Polyclonal Antibody Development R ..read more
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