Recent Review Explores Potential Relationship Between Food Allergy and the Gut Microbiome
Designs for Health Blog
by Anonymous
2d ago
According to recent research, the incidence of pathologies associated with the allergic response is increasing. Evidence suggests a potential link between gut microbial integrity and allergic diseases. This may be due to the role the gastrointestinal microbiome plays in the development and function of the immune system. A recent review article by Chernikova and colleagues has investigated the connection between food allergy and the gut microbiome. The body’s response to allergens is a complex process that involves immune and inflammatory pathways. It often manifests as conditions such as alle ..read more
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The Role of Soluble Fiber in Detoxification
Designs for Health Blog
by Anonymous
3d ago
Dietary fiber, such as glucomannan, may support liver detoxification and the successful elimination of toxins through healthy bowel movements. Liver detoxification is a process that mobilizes, transforms, and eliminates exogenous and endogenous toxicants from the body. The elimination action requires the aid of the kidneys, gallbladder, and intestines through the proper regulation and frequency of urine and bowel movements. Bile is synthesized by hepatocytes in the liver and serves as the major excretory route for toxic substances. After being synthesized, the bile is moved into the gallbladd ..read more
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Molybdenum: A Critical Cofactor for Normal Detoxification
Designs for Health Blog
by Anonymous
5d ago
Molybdenum is a trace element found in foods, such as legumes, leafy vegetables, grains, milk, and beef liver. Beans, particularly lima beans, peas, and small white beans, contain especially high amounts of molybdenum. It is considered an essential nutrient, which means it is required for biochemical processes within the human body, but is not made endogenously. Genetic mutations are the only reported common causes of molybdenum deficiencies. These gene-related molybdenum deficiencies have been associated with certain neurological and cardiac changes.  The body requires molybdenum for th ..read more
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Cruciferous Vegetables to Promote Liver Detox
Designs for Health Blog
by Anonymous
6d ago
The nutritional benefits of vegetables are well-known and accepted; they contain fiber, antioxidants, vitamins, minerals, and polyphenols. Cruciferous vegetables contain all these beneficial compounds and may be particularly helpful in promoting liver detoxification due to their unique sulfur-containing compounds called glucosinolates (GLS).  Cruciferous vegetables are members of the Brassicaceae or Cruciferae family, such as broccoli, cauliflower, cabbage, kale, Brussels sprouts, radish, mustard, and watercress. GLs are responsible for the pungent odor and bitter taste of cruciferous ve ..read more
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The Role of Citrus Pectin in Cellular Health and Immunometabolism
Designs for Health Blog
by Anonymous
1w ago
Citrus pectin is a molecule derived from citrus peels that is modified for commercial use to help support absorption in the small intestine. Oligosaccharides derived from citrus pectin are classified as nondigestible carbohydrates (NDC). Recent research indicates that NDCs may help support immunometabolism. NDCs may help support a healthy inflammatory response through their influence on toll-like receptor (TLR) 2 ectodomains and lipopolysaccharide-induced TLR4 activation.  Evidence suggests that pectin oligosaccharides may influence cytokines related to the inflammatory response. Laborat ..read more
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Recent Review Investigates Potential Link Between Quercetin and Neurodegenerative Health
Designs for Health Blog
by Anonymous
2w ago
Nuclear factor erythroid 2-related factor (Nrf2) is a transcription factor associated with more than 200 genes. It helps to support a healthy inflammatory response, antioxidative status, and preserve homeostasis in the presence of cellular stress. Recent research indicates that certain micronutrients such as quercetin may support the Nrf2 pathway and neurological health.  Berries, particularly dark berries, contain a relatively high amount of health-supportive compounds. These include flavonoids such as quercetin, which have been shown to support cellular health, antioxidative status, an ..read more
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Supportive Nutrients for Phase II Liver Detoxification
Designs for Health Blog
by Anonymous
2w ago
Every day the human body is exposed to hundreds of toxic substances like heavy metals, drugs (pharmaceutical or recreational), household cleaners, pollutants, and endogenous toxicants such as reactive oxygen species. Consequently, every day the human body must perform detoxification through the liver in two phases. Phase I liver detoxification was discussed last week. Phase II liver detoxification is the next step for successful toxin biotransformation and elimination.   After a toxin undergoes phase I detoxification through cytochrome P450 enzymes, it is deemed an “intermediate metaboli ..read more
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Glutathione to Support Cellular Function and Healthy Aging
Designs for Health Blog
by Anonymous
2w ago
Glutathione (GSH) is a critical molecule for the maintenance of antioxidative balance and helping protect cells from oxidative stress. GSH also promotes the optimal function of detoxification pathways, helping detoxify and eliminate toxins and other harmful substances from the body. GSH is produced endogenously, but the body may require increased amounts during the aging process or during times of increased toxic burden and oxidative stress. Deficiencies in GSH have been linked to certain chronic and age-related illnesses and diseases related to cellular and mitochondrial dysfunction. Type 2 ..read more
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Recent Review Investigates Relationship Between Gut Microbiome and Inflammatory Bowel Disease
Designs for Health Blog
by Anonymous
3w ago
Inflammatory bowel disease (IBD) is classified as two main types: ulcerative colitis (UC) and Crohn’s disease (CD). The complete etiology of IBD is not fully understood yet, however, it is believed to be the result of a combination of environmental factors, gut microbiome dysbiosis, genetic susceptibility, and autoimmune or unhealthy immune responses. Conditions involving chronic gastrointestinal (GI) inflammation, such as IBD, have been shown to involve an imbalance in GI microbiota and a reduction in bacterial diversity. This can cause downstream effects due to changes in the number of meta ..read more
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Supportive Nutrients for Phase I Liver Detoxification
Designs for Health Blog
by Anonymous
3w ago
Liver detoxification is a two-phase process essential for overall health in removing toxins from the body. It mobilizes exogenous and endogenous toxicants to undergo biotransformation and elimination through complex pathways. Both phases I and II liver detoxifications must be optimally functioning and balanced with the assistance of healthy lifestyle habits and a myriad of required, supportive nutrients. Various macronutrients and micronutrients are required for proper phase I detoxification performed by a group of enzymes called cytochrome P450 (P450). The P450 enzymes transform lipid-solubl ..read more
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