PLOS Biology
2,515 FOLLOWERS
PLOS Biology publishes significant advances across the biological sciences. And we push boundaries. Designed to advance science and the communities who depend upon it, we're transforming research communication to fit the research process.
PLOS Biology
7h ago
by Gokul Gopinathan, Qian Xu, Xianghong Luan, Thomas G. H. Diekwisch
The densely packed centromeric heterochromatin at minor and major satellites is comprised of H3K9me2/3 histones, the heterochromatin protein HP1α, and histone variants. In the present study, we sought to determine the mechanisms by which condensed heterochromatin at major and minor satellites stabilized by the chromatin factor CFDP1 affects the activity of the small GTPase Ran as a requirement for spindle formation. CFDP1 colocalized with heterochromatin at major and minor satellites and was essential for the structural stabi ..read more
PLOS Biology
3d ago
by John P. McCutcheon, Arkadiy I. Garber, Noah Spencer, Jessica M. Warren
The move from a free-living environment to a long-term residence inside a host eukaryotic cell has profound effects on bacterial function. While endosymbioses are found in many eukaryotes, from protists to plants to animals, the bacteria that form these host-beneficial relationships are even more diverse. Endosymbiont genomes can become radically smaller than their free-living relatives, and their few remaining genes show extreme compositional biases. The details of how these reduced and divergent gene sets work, and how ..read more
PLOS Biology
3d ago
by Emmi Schlicht, Carol Gilsenan, Peter Santema, Agnes Türk, Andrea Wittenzellner, Bart Kempenaers
In animals, reproductive performance typically improves over time early in life. Several ultimate and proximate mechanisms may contribute to such an age-related improvement and these mechanisms can act in a relative or in an absolute sense. Low performance of young individuals may be the consequence of a comparison or competition with older individuals (relative), or it may be due to specific traits of young individuals and be unrelated to the presence of older competitors (absolute). Here, we pe ..read more
PLOS Biology
5d ago
by Alexander Strudwick Young
Genome-wide association studies (GWASs) can be affected by confounding. Family-based GWAS uses random, within-family genetic variation to avoid this. A study in PLOS Biology details how different sources of confounding affect GWAS and whether family-based designs offer a solution. Genome-wide association studies (GWASs) can be affected by confounding, but family-based GWASs use random, within-family genetic variation to avoid this. This Primer explores a study in PLOS Biology which asks how different sources of confounding affect GWASs and whether family-based desi ..read more
PLOS Biology
5d ago
by Michael A. Brockhurst, Duncan D. Cameron, Andrew P. Beckerman
Endosymbiosis drives evolutionary innovation and underpins the function of diverse ecosystems. The mechanistic origins of symbioses, however, remain unclear, in part because early evolutionary events are obscured by subsequent evolution and genetic drift. This Essay highlights how experimental studies of facultative, host-switched, and synthetic symbioses are revealing the important role of fitness trade-offs between within-host and free-living niches during the early-stage evolution of new symbiotic associations. The mutational ..read more
PLOS Biology
5d ago
by Laila P. Partida-Martínez
Rhizopus microsporus is an example of a fungal holobiont. Strains of this species can harbor bacterial and viral endosymbionts inherited by the next generation. These microbial allies increase pathogenicity and defense and control asexual and sexual reproduction. Rhizopus microsporus is an example of a fungal holobiont, harboring bacterial and viral endosymbionts. This Perspective article discusses how these microbial allies increase pathogenicity and defense and control asexual and sexual reproduction in the fungus ..read more
PLOS Biology
5d ago
by Thomas A. Richards, Nancy A. Moran
How do distinct species cofunction in symbiosis, despite conflicting interests? A new collection of articles explores emerging themes as researchers exploit modern research tools and new models to unravel how symbiotic interactions function and evolve. This editorial discusses a new collection of articles exploring emerging themes in symbiosis research, as researchers exploit modern research tools and new models to unravel how symbiotic interactions function and evolve ..read more
PLOS Biology
1w ago
by Szymon M. Drobniak, Malgorzata Lagisz, Yefeng Yang, Shinichi Nakagawa
A recent article claimed that researchers need not increase the overall sample size for a study that includes both sexes. This Formal Comment points out that that study assumed two sexes to have the same variance, and explains why this is a unrealistic assumption ..read more
PLOS Biology
1w ago
by N. Sören Häfker, Laurenz Holcik, Audrey M. Mat, Aida Ćorić, Karim Vadiwala, Isabel Beets, Alexander W. Stockinger, Carolina E. Atria, Stefan Hammer, Roger Revilla-i-Domingo, Liliane Schoofs, Florian Raible, Kristin Tessmar-Raible
The circadian clock controls behavior and metabolism in various organisms. However, the exact timing and strength of rhythmic phenotypes can vary significantly between individuals of the same species. This is highly relevant for rhythmically complex marine environments where organismal rhythmic diversity likely permits the occupation of different microenvironments ..read more