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The nematode-trapping fungus Arthrobotrys oligospora detects prey pheromones via G protein-coupled receptors

Nature » Microbiology

by Chih-Yen Kuo, Rebecca J. Tay, Hung-Che Lin, Sheng-Chian Juan, Guillermo Vidal-Diez de Ulzurrun, Yu-Chu Chang, Jason Hoki, Frank C. Schroeder, Yen-Ping Hsueh

2d ago

Nature Microbiology, Published online: 22 April 2024; doi:10.1038/s41564-024-01679-w Nematode signals such as ascarosides are sensed by G protein-coupled receptors of a nematode-trapping fungus, resulting in fungal activation of cAMP–PKA signalling and trap development ..read more

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Targeted accurate RNA consensus sequencing (tARC-seq) reveals mechanisms of replication error affecting SARS-CoV-2 divergence

Nature » Microbiology

by Catherine C. Bradley, Chen Wang, Alasdair J. E. Gordon, Alice X. Wen, Pamela N. Luna, Matthew B. Cooke, Brendan F. Kohrn, Scott R. Kennedy, Vasanthi Avadhanula, Pedro A. Piedra, Olivier Lichtarge, Chad A. Shaw, Shannon E. Ronca, Christophe Herman

2d ago

Nature Microbiology, Published online: 22 April 2024; doi:10.1038/s41564-024-01655-4 Targeted accurate RNA consensus sequencing enables study of de novo errors caused by RNA-dependent RNA polymerases and provides deeper insights into how SARS-CoV-2 genetic diversity emerges ..read more

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Cerastecins inhibit membrane lipooligosaccharide transport in drug-resistant Acinetobacter baumannii

Nature » Microbiology

by Hao Wang, Andrii Ishchenko, Jason Skudlarek, Pamela Shen, Liudmila Dzhekieva, Ronald E. Painter, Yun-Ting Chen, Marina Bukhtiyarova, Andrew Leithead, Rodger Tracy, Kerim Babaoglu, Carolyn Bahnck-Teets, Alexei Buevich, Tamara D. Cabalu, Marc Labroli, Henry Lange, Ying Lei, Wei Li, Jian Liu, Paul A. Mann, Tao Meng, Helen J. Mitchell, James Mulhearn, Giovanna Scapin, Deyou Sha, Anthony W. Shaw, Qian Si, Ling Tong, Chengwei Wu, Zhe Wu, Jing Chen Xiao, Min Xu, Li-Kang Zhang, David McKenney, Randy R. Miller, Todd A. Black, Andrew Cooke, Carl J. Balibar, Daniel J. Klein, Izzat Raheem, Scott S. Walker

2d ago

Nature Microbiology, Published online: 22 April 2024; doi:10.1038/s41564-024-01667-0 Antibiotics to treat carbapenem-resistant Acinetobacter baumannii infection are an urgent need. The cerastecins are potent, bactericidal and efficacious in animal models of infection, and may enable new treatment modalities targeting LOS transport ..read more

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Infection with mpox virus via the genital mucosae increases shedding and transmission in the multimammate rat (Mastomys natalensis)

Nature » Microbiology

by Julia R. Port, Jade C. Riopelle, Samuel G. Smith, Lara Myers, Franziska K. Kaiser, Matthew C. Lewis, Shane Gallogly, Atsushi Okumura, Trent Bushmaker, Jonathan E. Schulz, Rebecca Rosenke, Jessica Prado-Smith, Aaron Carmody, Sidy Bane, Brian J. Smith, Greg Saturday, Heinz Feldmann, Kyle Rosenke, Vincent J. Munster

2d ago

Nature Microbiology, Published online: 22 April 2024; doi:10.1038/s41564-024-01666-1 Comparing infection routes and subsequent transmission of MPXV in the multimammate rat (Mastomys natalensis) indicates increased susceptibility, shedding and transmission via the genital mucosae ..read more

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Interferon-induced transmembrane protein-1 competitively blocks Ephrin receptor A2-mediated Epstein–Barr virus entry into epithelial cells

Nature » Microbiology

by Yinggui Yang, Tengteng Ding, Ying Cong, Xiaomin Luo, Changlin Liu, Ting Gong, Min Zhao, Xichun Zheng, Chenglin Li, Yuanbin Zhang, Jiayi Zhou, Chuping Ni, Xueyu Zhang, Ziliang Ji, Tao Wu, Shaodong Yang, Qingchun Zhou, Dinglan Wu, Xinqi Gong, Qingyou Zheng, Xin Li

2d ago

Nature Microbiology, Published online: 22 April 2024; doi:10.1038/s41564-024-01659-0 IFITM1 can compete with EBV glycoproteins for EphA2 binding and prevent virus entry into epithelial cells, in vitro and in vivo. YTHDF3 suppresses IFITM1 via the degradation-related protein DDX5 ..read more

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Phage defence system CBASS is regulated by a prokaryotic E2 enzyme that imitates the ubiquitin pathway

Nature » Microbiology

by Yan Yan, Jun Xiao, Fengtao Huang, Wei Xian, Bingbing Yu, Rui Cheng, Hui Wu, Xueling Lu, Xionglue Wang, Wenjing Huang, Jing Li, Greater Kayode Oyejobi, Carol V. Robinson, Hao Wu, Di Wu, Xiaoyun Liu, Longfei Wang, Bin Zhu

2d ago

Nature Microbiology, Published online: 22 April 2024; doi:10.1038/s41564-024-01684-z Here the authors show that anti-phage signalling in the CBASS immune system is activated by a ubiquitination-like poly-cGASylation mechanism ..read more

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Narrow-spectrum antibiotic exploits metabolic differences to inhibit Pseudomonas aeruginosa

Nature » Microbiology

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4d ago

Nature Microbiology, Published online: 19 April 2024; doi:10.1038/s41564-024-01673-2 We characterize the activity of fluorofolin, a potent inhibitor of dihydrofolate reductase, against Pseudomonas aeruginosa. By exploiting a divergence in thymidine metabolism, fluorofolin becomes selective for P. aeruginosa in the presence of thymine, demonstrating that it can be a narrow-spectrum antibiotic for this bacterial pathogen ..read more

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Diet switch pre-vaccination improves immune response and metabolic status in formerly obese mice

Nature » Microbiology

by Rebekah Honce, Ana Vazquez-Pagan, Brandi Livingston, Alexandra H. Mandarano, Benjamin A. Wilander, Sean Cherry, Virginia Hargest, Bridgett Sharp, Pamela H. Brigleb, Ericka Kirkpatrick Roubidoux, Lee-Ann Van de Velde, R. Chris Skinner, Maureen A. McGargill, Paul G. Thomas, Stacey Schultz-Cherry

4d ago

Nature Microbiology, Published online: 18 April 2024; doi:10.1038/s41564-024-01677-y Diet switching from high-fat to standard diet before influenza vaccination affects the metabolic state of T cells, restores their responses and improves vaccine efficacy in mice ..read more

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TRNA modification reprogramming contributes to artemisinin resistance in Plasmodium falciparum

Nature » Microbiology

by Jennifer L. Small-Saunders, Ameya Sinha, Talia S. Bloxham, Laura M. Hagenah, Guangxin Sun, Peter R. Preiser, Peter C. Dedon, David A. Fidock

4d ago

Nature Microbiology, Published online: 17 April 2024; doi:10.1038/s41564-024-01664-3 Artemisinin-resistant Plasmodium falciparum can use tRNA modification reprogramming and codon bias translation as an epitranscriptomic response to survive artemisinin-induced stress ..read more

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Age-specific nasal epithelial responses to SARS-CoV-2 infection

Nature » Microbiology

by Maximillian N. J. Woodall, Ana-Maria Cujba, Kaylee B. Worlock, Katie-Marie Case, Tereza Masonou, Masahiro Yoshida, Krzysztof Polanski, Ni Huang, Rik G. H. Lindeboom, Lira Mamanova, Liam Bolt, Laura Richardson, Batuhan Cakir, Samuel Ellis, Machaela Palor, Thomas Burgoyne, Andreia Pinto, Dale Moulding, Timothy D. McHugh, Aarash Saleh, Eliz Kilich, Puja Mehta, Chris O’Callaghan, Jie Zhou, Wendy Barclay, Paolo DeCoppi, Colin R. Butler, Mario Cortina-Borja, Heloise Vinette, Sunando Roy, Judith Breuer, Rachel C. Chambers, Wendy E. Heywood, Kevin Mills, Robert E. Hynds, Sarah A. Teichmann, Kerstin B. Meyer, Marko Z. Nikolić, Claire M. Smith

1w ago

Nature Microbiology, Published online: 15 April 2024; doi:10.1038/s41564-024-01658-1 Age-specific differences upon SARS-CoV-2 infection are marked by emergence of goblet 2 inflammatory cells expressing antiviral interferon stimulating genes in paediatric nasal cultures, and basaloid-like cells with increased viral spread in cultures from older adults ..read more

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