Targeting the mosquito prefoldin–chaperonin complex blocks Plasmodium transmission
Nature » Microbiology
by Yuemei Dong, Seokyoung Kang, Simone L. Sandiford, Andrew Pike, Maria L. Simões, Ratawan Ubalee, Kevin Kobylinski, George Dimopoulos
1w ago
Nature Microbiology, Published online: 06 March 2025; doi:10.1038/s41564-025-01947-3 Disrupting the prefoldin–chaperonin complex in various species of Anopheles mosquitoes results in a compromised intestinal barrier leading to an immune response that inhibits the malaria parasite ..read more
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Publisher Correction: Intestinal crypt microbiota modulates intestinal stem cell turnover and tumorigenesis via indole acetic acid
Nature » Microbiology
by Shuning Zhang, Lihua Peng, Shyamal Goswami, Yuchen Li, Haiyue Dang, Shuli Xing, Panpan Feng, Giulia Nigro, Yingying Liu, Yingfei Ma, Tianhao Liu, Jiahua Yang, Tinglei Jiang, Yingnan Yang, Nick Barker, Philippe Sansonetti, Parag Kundu
1w ago
Nature Microbiology, Published online: 06 March 2025; doi:10.1038/s41564-025-01976-y Publisher Correction: Intestinal crypt microbiota modulates intestinal stem cell turnover and tumorigenesis via indole acetic acid ..read more
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Microplastic research must consider microbes
Nature » Microbiology
by
1w ago
Nature Microbiology, Published online: 05 March 2025; doi:10.1038/s41564-025-01960-6 It is increasingly clear that microplastic pollution can be detrimental to human, animal and environmental health. More research is needed to determine if and how our microbial partners are also negatively impacted, and what this means for host and ecosystem health ..read more
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Dietary fibre counters the oncogenic potential of colibactin-producing Escherichia coli in colorectal cancer
Nature » Microbiology
by Bhupesh Kumar Thakur, Yann Malaise, Saurav Roy Choudhury, Anna Neustaeter, Williams Turpin, Catherine Streutker, Julia Copeland, Erin O. Y. Wong, William W. Navarre, David S. Guttman, Christian Jobin, Kenneth Croitoru, Alberto Martin
1w ago
Nature Microbiology, Published online: 03 March 2025; doi:10.1038/s41564-025-01938-4 Reduced dietary fibre together with mutations in the host mismatch repair machinery promote colon carcinogenesis by increasing inflammation, nitrate-fuelled growth of colibactin-producing Escherichia coli and colibactin-dependent genotoxic tissue damage ..read more
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The sweet side of IL-22
Nature » Microbiology
by Jochem H. Bernink
1w ago
Nature Microbiology, Published online: 03 March 2025; doi:10.1038/s41564-025-01945-5 Dysbiosis is a harbinger of severe intestinal pathologies driving enhanced susceptibility to colonization by opportunistic pathogens. Type 3 innate lymphoid cell-derived IL-22 harnesses pathogen colonization resistance by regulating the galactosylation status of intestinal epithelial cells ..read more
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Climate change will amplify the impacts of harmful microorganisms in aquatic ecosystems
Nature » Microbiology
by Justin R. Seymour, Sandra L. McLellan
2w ago
Nature Microbiology, Published online: 28 February 2025; doi:10.1038/s41564-025-01948-2 Here the authors discuss the influence of aquatic microbiomes on the health and economies of human populations and examine how climate changes might impact these dynamics ..read more
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One-carbon fixation via the synthetic reductive glycine pathway exceeds yield of the Calvin cycle
Nature » Microbiology
by Beau Dronsella, Enrico Orsi, Helena Schulz-Mirbach, Sara Benito-Vaquerizo, Suzan Yilmaz, Timo Glatter, Arren Bar-Even, Tobias J. Erb, Nico J. Claassens
2w ago
Nature Microbiology, Published online: 27 February 2025; doi:10.1038/s41564-025-01941-9 An engineered one-carbon-fixation pathway increases biomass yields of Cupriavidus necator compared with the Calvin cycle and can support future, sustainable bio-based production ..read more
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Rethinking concepts of virulence with Neisseria gonorrhoeae
Nature » Microbiology
by Alison K. Criss
2w ago
Nature Microbiology, Published online: 27 February 2025; doi:10.1038/s41564-025-01946-4 Alison Criss discusses the features of Neisseria gonorrhoeae, its intricate interactions with innate immunity and how this challenges our understanding of what makes a pathogen pathogenic ..read more
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Surpassing natural limits in one-carbon assimilation
Nature » Microbiology
by Arslan Sarwar, Eun Yeol Lee
2w ago
Nature Microbiology, Published online: 27 February 2025; doi:10.1038/s41564-025-01943-7 Synthetic one-carbon assimilation pathways can offer faster and more efficient alternatives to their native counterparts, enabling enhanced bio-based production of fuels and chemicals from one-carbon substrates ..read more
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CRISPRi-ART enables functional genomics of diverse bacteriophages using RNA-binding dCas13d
Nature » Microbiology
by Benjamin A. Adler, Muntathar J. Al-Shimary, Jaymin R. Patel, Emily G. Armbruster, David Colognori, Emeric J. Charles, Kate V. Miller, Arushi Lahiri, Michael L. Cui, Agnès Oromí-Bosch, Angela Voelker, Marena Trinidad, Jina Lee, Sebastien Beurnier, Ron Boger, Jason Nomburg, Rodolphe Barrangou, Vivek K. Mutalik, Joseph S. Schoeniger, Joseph A. Pogliano, David F. Savage, Jennifer A. Doudna, Brady F. Cress
2w ago
Nature Microbiology, Published online: 26 February 2025; doi:10.1038/s41564-025-01935-7 Leveraging RNA-targeting dCas13d enables selective interference with phage protein translation and facilitates measurement of phage gene fitness at a transcriptome-wide scale ..read more
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