Secretion of the fungal toxin candidalysin is dependent on conserved precursor peptide sequences
Nature » Microbiology
by Rita Müller, Annika König, Sabrina Groth, Robert Zarnowski, Corissa Visser, Tom Handrianz, Corinne Maufrais, Thomas Krüger, Maximilian Himmel, Sejeong Lee, Emily L. Priest, Deniz Yildirim, Jonathan P. Richardson, Matthew G. Blango, Marie-Elisabeth Bougnoux, Olaf Kniemeyer, Christophe d’Enfert, Axel A. Brakhage, David R. Andes, Verena Trümper, Christian Nehls, Lydia Kasper, Selene Mogavero, Thomas Gutsmann, Julian R. Naglik, Stefanie Allert, Bernhard Hube
4d ago
Nature Microbiology, Published online: 22 February 2024; doi:10.1038/s41564-024-01606-z The Candida albicans toxin, candidalysin, is embedded in an unusual conserved precursor peptide sequence (Ece1). The precursor is not required to block premature pore-forming toxicity, but rather to prevent candidalysin auto-aggregation ..read more
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A rhesus macaque model of human norovirus infection
Nature » Microbiology
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5d ago
Nature Microbiology, Published online: 20 February 2024; doi:10.1038/s41564-023-01597-3 Human norovirus infection is a major global health concern, but a suitable animal model is lacking. We have established repeated infection with human norovirus in rhesus macaques via oral challenge. Animals demonstrate virus shedding in the stool and subsequent serum antibody responses, and virus replication is detected in the small intestine ..read more
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Vitamin A deficiency impairs neutrophil-mediated control of Salmonella via SLC11A1 in mice
Nature » Microbiology
by Kristen L. Lokken-Toyli, Vladimir E. Diaz-Ochoa, Lizbeth Camacho, Annica R. Stull-Lane, Amber E. R. Van Hecke, Jason P. Mooney, Ariel D. Muñoz, Gregory T. Walker, Daniela Hampel, Xiaowen Jiang, Jasmine C. Labuda, Claire E. Depew, Stephen J. McSorley, Charles B. Stephensen, Renée M. Tsolis
5d ago
Nature Microbiology, Published online: 19 February 2024; doi:10.1038/s41564-024-01613-0 Vitamin A deficiency exacerbates invasive non-typhoidal Salmonella infection in mice, revealing a restrictive role for SLC11A1 in neutrophils ..read more
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Publisher Correction: A non-human primate model for human norovirus infection
Nature » Microbiology
by Inga Rimkute, Natthawan Chaimongkol, Kamron D. Woods, Bianca M. Nagata, Samuel Darko, Sucheta Gudbole, Amy R. Henry, Stanislav V. Sosnovtsev, Adam S. Olia, Raffaello Verardi, Karin Bok, John-Paul Todd, Ruth Woodward, Peter D. Kwong, Daniel C. Douek, Derron A. Alves, Kim Y. Green, Mario Roederer
1w ago
Nature Microbiology, Published online: 15 February 2024; doi:10.1038/s41564-024-01636-7 Publisher Correction: A non-human primate model for human norovirus infection ..read more
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Hunting emerging viruses through participatory community science
Nature » Microbiology
by Christine Marizzi, Latasha Wright
1w ago
Nature Microbiology, Published online: 14 February 2024; doi:10.1038/s41564-024-01604-1 A participatory research initiative generates actionable data on avian diseases in New York City, showcases how a community-based approach can tackle misinformation, and actively engages students from historically underrepresented communities in science, technology, engineering and maths ..read more
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A conserved interdomain microbial network underpins cadaver decomposition despite environmental variables
Nature » Microbiology
by Zachary M. Burcham, Aeriel D. Belk, Bridget B. McGivern, Amina Bouslimani, Parsa Ghadermazi, Cameron Martino, Liat Shenhav, Anru R. Zhang, Pixu Shi, Alexandra Emmons, Heather L. Deel, Zhenjiang Zech Xu, Victoria Nieciecki, Qiyun Zhu, Michael Shaffer, Morgan Panitchpakdi, Kelly C. Weldon, Kalen Cantrell, Asa Ben-Hur, Sasha C. Reed, Greg C. Humphry, Gail Ackermann, Daniel McDonald, Siu Hung Joshua Chan, Melissa Connor, Derek Boyd, Jake Smith, Jenna M. S. Watson, Giovanna Vidoli, Dawnie Steadman, Aaron M. Lynne, Sibyl Bucheli, Pieter C. Dorrestein, Kelly C. Wrighton, David O. Carter, Rob Knight, Jessica L. Metcalf
1w ago
Nature Microbiology, Published online: 12 February 2024; doi:10.1038/s41564-023-01580-y A conserved network of bacteria and fungi underpins cadaver decomposition despite selection effects of location, climate and season ..read more
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Decomposer communities are universal in death
Nature » Microbiology
by Michael S. Strickland, Laurel Lynch
1w ago
Nature Microbiology, Published online: 12 February 2024; doi:10.1038/s41564-023-01576-8 Decomposer microbiomes are universal across cadavers regardless of environmental conditions, and they use complex cross-feeding and interkingdom interactions to break down organic matter ..read more
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Synthesis of lipid-linked precursors of the bacterial cell wall is governed by a feedback control mechanism in Pseudomonas aeruginosa
Nature » Microbiology
by Lindsey S. Marmont, Anna K. Orta, Becca W. A. Baileeves, David Sychantha, Ana Fernández-Galliano, Yancheng E. Li, Neil G. Greene, Robin A. Corey, Phillip J. Stansfeld, William M. Clemons Jr, Thomas G. Bernhardt
2w ago
Nature Microbiology, Published online: 09 February 2024; doi:10.1038/s41564-024-01603-2 Peptidoglycan biosynthesis is regulated by a feedback mechanism preventing the pathway from sequestering essential lipid carriers used to assemble and transport surface glycan subunits ..read more
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Genome-wide association study identifies human genetic variants associated with fatal outcome from Lassa fever
Nature » Microbiology
by Dylan Kotliar, Siddharth Raju, Shervin Tabrizi, Ikponmwosa Odia, Augustine Goba, Mambu Momoh, John Demby Sandi, Parvathy Nair, Eric Phelan, Ridhi Tariyal, Philomena E. Eromon, Samar Mehta, Refugio Robles-Sikisaka, Katherine J. Siddle, Matt Stremlau, Simbirie Jalloh, Stephen K. Gire, Sarah Winnicki, Bridget Chak, Stephen F. Schaffner, Matthias Pauthner, Elinor K. Karlsson, Sarah R. Chapin, Sharon G. Kennedy, Luis M. Branco, Lansana Kanneh, Joseph J. Vitti, Nisha Broodie, Adrianne Gladden-Young, Omowunmi Omoniwa, Pan-Pan Jiang, Nathan Yozwiak, Shannon Heuklom, Lina M. Moses, George O. Akpede, Danny A. Asogun, Kathleen Rubins, Susan Kales, Anise N. Happi, Christopher O. Iruolagbe, Mercy Dic-Ijiewere, Kelly Iraoyah, Omoregie O. Osazuwa, Alexander K. Okonkwo, Stefan Kunz, Joseph B. McCormick, S. Humarr Khan, Anna N. Honko, Eric S. Lander, Michael B. A. Oldstone, Lisa Hensley, Onikepe A. Folarin, Sylvanus A. Okogbenin, Stephan Günther, Hanna M. Ollila, Ryan Tewhey, Peter O. Okokhere, John S. Schieffelin, Kristian G. Andersen, Steven K. Reilly, Donald S. Grant, Robert F. Garry, Kayla G. Barnes, Christian T. Happi, Pardis C. Sabeti
2w ago
Nature Microbiology, Published online: 07 February 2024; doi:10.1038/s41564-023-01589-3 GWAS in difficult-to-recruit populations identifies variants associated with Lassa fever outcome and susceptibility at loci proximal to LIF, GRM7 and LARGE1 ..read more
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COBRA improves the completeness and contiguity of viral genomes assembled from metagenomes
Nature » Microbiology
by LinXing Chen, Jillian F. Banfield
2w ago
Nature Microbiology, Published online: 06 February 2024; doi:10.1038/s41564-023-01598-2 Contig overlap-based reassembly enables the generation of accurate and high-quality viral genomes from assembled metagenomes ..read more
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