Nurse Nacole
1,216 FOLLOWERS
Nacole Riccaboni is a board-certified registered nurse, blogs about advanced nursing education and being a new nurse. She posts daily nursing tips, bedside nursing resources, practices, along with advice on nursing academics, licensing exams, professionalism, and nursing school success.
Nurse Nacole
5h ago
Category: Fundamentals
ACE inhibitors act on the ACE enzyme that generates angiotensin II from angiotensin I and inactivates the breakdown of bradykinin. Angiotensin I originates in the liver from angiotensinogen under the influence of the enzyme renin ..read more
Nurse Nacole
16h ago
Category: Fundamentals
Calcium channel blockers have many important drug interactions. Diltiazem and verapamil interact with digoxin and cyclosporine, among others. They increase digoxin levels and increase plasma levels of cyclosporine ..read more
Nurse Nacole
2d ago
Category: Fundamentals
Nondihydropyridine calcium channel blockers are contraindicated in patients with bradycardia, sick sinus syndrome or more advanced heart block (in the absence of a pacemaker). Caution must be used in patients with atrial tachyarrhythmias ..read more
Nurse Nacole
3d ago
Category: Fundamentals
Higher doses of dihydropyridine calcium channel blockers often result in some degree of edema, and can additionally cause flushing, headache and tachycardia. Lower extremity edema is the most commonly observed of these side effects ..read more
Nurse Nacole
4d ago
Category: Fundamentals
Calcium channel blockers act primarily to reduce peripheral vascular resistance and, within the renal vasculature, produce natriuresis by increasing renal blood flow, dilating afferent arterioles and increasing glomerular filtration pressure ..read more
Nurse Nacole
5d ago
Category: Fundamentals
Calcium channel blockers impede the movement of extracellular calcium through ion-specific channels within the cell wall. This ultimately reduces calcium flux inward, which results in arterial dilation via smooth muscle relaxation ..read more
Nurse Nacole
6d ago
Category: Fundamentals
Metolazone is a powerful thiazide diuretic with a quinazoline structure. An important advantage of metolazone is efficacy even despite decreased kidney function and is usually used in concert with loop diuretics for edema management ..read more
Nurse Nacole
1w ago
Category: Fundamentals
Among thiazide-type diuretics, hydrochlorothiazide is the most widely used. It has a bioavailability ranging from 60% to 80%. Its absorption may be decreased in heart failure and/or chronic kidney disease ..read more
Nurse Nacole
1w ago
Category: Fundamentals
Thiazide-type diuretics as a class differ from the loop diuretics in that they have a longer duration and site of action. Additionally, thiazides are so-called low-ceiling diuretics, because the maximal response is reached at a relatively low dose ..read more
Nurse Nacole
1w ago
Category: Fundamentals
Loop diuretics, including the most commonly used furosemide and torsemide, inhibit the Na+/K+/2Cl- cotransporter associated with the transport of chloride across the lining cells of the ascending limb of the loop of Henle ..read more