CellPress | Neuron Journal
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Neuron publishes ground-breaking research papers, reviews & commentary across neuroscience and is a premier intellectual forum for the neuroscience community.
CellPress | Neuron Journal
1d ago
Insomnia is an important comorbidity of chronic pain. In this issue of Neuron, Li et al. report that chronic-pain-induced insomnia is mediated by the pyramidal neurons in the anterior cingulate cortex and their dopaminergic projections to the dorsal medial striatum ..read more
CellPress | Neuron Journal
1d ago
In this issue of Neuron, Yamada et al.1 show that fast excitatory neurotransmission by protons acting at acid-sensing ion channels (ASICs) mediates mechanical force-evoked signaling at the Merkel cell-neurite complex (MNC), contributing to mammalian tactile discrimination ..read more
CellPress | Neuron Journal
1d ago
In this issue of Neuron, Ke et al. report a novel non-canonical interaction between 14-3-3θ and TDP-43 that impacts loss-of-function and gain-of-toxic pathology in TDP-43 proteinopathies. The authors further provide proof of principle for a 14-3-3θ-targeted gene therapy to reduce TDP-43-induced deficits in transgenic TDP-43 mutant mice ..read more
CellPress | Neuron Journal
1d ago
Removal of toxic debris that can hinder brain function is performed primarily by microglia, the brain’s professional phagocytes. A recent study in Cell1 identified that viral response interferons are required for priming microglia, ensuring competent phagocytosis and proper circuit wiring ..read more
CellPress | Neuron Journal
1d ago
Ocklenburg and Guo review the current state of knowledge on cross-hemispheric communication in the vertebrate brain, with a focus on recent research in rodents. They discuss how lateralization in sensory, memory, and motor functions can emerge from asymmetric cross-hemispheric communication ..read more
CellPress | Neuron Journal
1d ago
Gradwell et al. highlight the medial deep dorsal horn as a hub for sensory convergence in the spinal cord. Within this region, they identify a population of glycinergic inhibitory interneurons providing broad ipsilateral inhibition to pre-motor and motor networks to gate cutaneous-evoked muscle activity, ensuring smooth movement transitions ..read more
CellPress | Neuron Journal
1d ago
This review by Lopez-Lee and Torres et al. summarizes sex-specific differences in AD and potential biological mechanisms and discusses how sex hormones and chromosomes may influence inflammation, metabolism, and autophagy in aging, contributing to distinct disease patterns in men and women ..read more
CellPress | Neuron Journal
1d ago
Social memory consists of both familiarity detection and recollection of past social episodes. Whether and how the hippocampus fulfills these roles is unclear. Boyle, Posani, et al. find that the hippocampal CA2 region meets the distinct computational demands of these processes through tuning the geometry of structured neural activity ..read more
CellPress | Neuron Journal
1d ago
Kawatake-Kuno, Li, Inaba, et al. considered a midline thalamic structure, the aPVT, a crucial brain region involved in the sustained antidepressant-like effects of the ketamine metabolite (2S,6S)-HNK. Moreover, they uncover the mechanisms whereby this drug drives its antidepressant-like effects via modulation of GABAergic-inhibition-mediated epigenetic regulations in the aPVT ..read more
CellPress | Neuron Journal
1d ago
TDP-43 forms neuronal deposits in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) due to unknown causes. Ke et al. identified the TDP-43 interactor 14-3-3θ, which promotes TDP-43 deposition. They devised a treatment harnessing 14-3-3θ’s affinity for TDP-43, mitigating deficits and neurodegeneration in ALS/FTD models with implications for future therapy ..read more