Pharmaceuticals, Vol. 17, Pages 552: Comparative Investigation of pH–Dependent Availability of Pancreatic Enzyme Preparations In Vitro Pharmaceuticals doi: 10.3390/ph17050552 Authors: Amy Todd Emma Bennett-Huntley Jonas Rosendahl Jürgen Schnekenburger Waldemar Uhl This study aimed to compare different pancreatic enzyme preparations (PEPs) available in Germany regarding particle geometry and size, and to evaluate enzyme activity under physiologically relevant conditions in vitro. Pancreatic endocrine insufficiency is characterized by deficiency of pancreatic enzymes resulting in maldi ..read more

Pharmaceuticals, Vol. 17, Pages 551: In Silico Prediction of New Inhibitors for Kirsten Rat Sarcoma G12D Cancer Drug Target Using Machine Learning-Based Virtual Screening, Molecular Docking, and Molecular Dynamic Simulation Approaches Pharmaceuticals doi: 10.3390/ph17050551 Authors: Amar Ajmal Muhammad Danial Maryam Zulfat Muhammad Numan Sidra Zakir Chandni Hayat Khulood Fahad Alabbosh Magdi E. A. Zaki Arif Ali Dongqing Wei Single-point mutations in the Kirsten rat sarcoma (KRAS) viral proto-oncogene are the most common cause of human cancer. In humans, oncogenic KRAS mutations are responsible ..read more

Pharmaceuticals, Vol. 17, Pages 548: NMI-SO2Cl2-Mediated Amide Bond Formation: Facile Synthesis of Some Dihydrotriazolopyrimidine Amide Derivatives as Potential Anti-Inflammatory and Anti-Tubercular Agents Pharmaceuticals doi: 10.3390/ph17050548 Authors: Aravinda Babu Kenchaiah Sunil Ayyiliath Meleveetil Sajith Eeda Koti Reddy Sougata Santra Grigory V. Zyryanov Talavara Venkatesh Somashekara Bhadrachari Muthipeedika Nibin Joy Facile access to some novel biologically relevant dihydrotriazolopyrimidine carboxylic acid-derived amide analogues using NMI/SO2Cl2, and aromatic and aliphatic primary a ..read more

Pharmaceuticals, Vol. 17, Pages 549: Structure–Activity Relationship of Synthetic Linear KTS-Peptides Containing Meta-Aminobenzoic Acid as Antagonists of α1β1 Integrin with Anti-Angiogenic and Melanoma Anti-Tumor Activities Pharmaceuticals doi: 10.3390/ph17050549 Authors: Majdi Saleem Naamneh Tatjana Momic Michal Klazas Julius Grosche Johannes A. Eble Cezary Marcinkiewicz Netaly Khazanov Hanoch Senderowitz Amnon Hoffman Chaim Gilon Jehoshua Katzhendler Philip Lazarovici To develop peptide drugs targeting integrin receptors, synthetic peptide ligands endowed with we ..read more

Pharmaceuticals, Vol. 17, Pages 550: Mucoadhesive Budesonide Solution for the Treatment of Pediatric Eosinophilic Esophagitis Pharmaceuticals doi: 10.3390/ph17050550 Authors: Antonio Spennacchio Antonio Lopalco Giuseppe Francesco Racaniello Annalisa Cutrignelli Flavia Maria la Forgia Sergio Fontana Fernanda Cristofori Ruggiero Francavilla Angela Assunta Lopedota Nunzio Denora Eosinophilic Esophagitis is an antigen-mediated inflammatory disease characterized by thickening of the esophageal wall, leading to dysphagia, vomiting, reflux, and abdominal pain. This disease can be treated with a thera ..read more

Pharmaceuticals, Vol. 17, Pages 546: In Vivo Evaluation of Miconazole-Nitrate-Loaded Transethosomal Gel Using a Rat Model Infected with Candida albicans Pharmaceuticals doi: 10.3390/ph17050546 Authors: Zara Asghar Talha Jamshaid Usama Jamshaid Asadullah Madni Naheed Akhtar Manar O. Lashkar Heba A. Gad Miconazole nitrate (MCNR), an antifungal drug, is used to treat superficial infections. The objective of the current study was to assess the antifungal effectiveness of MCNR-loaded transethosomal gel (MNTG) against Candida albicans in an in vivo rat model. The outcomes were compared with those of ..read more

Pharmaceuticals, Vol. 17, Pages 547: Cholinergic Stimulation Exerts Cardioprotective Effects and Alleviates Renal Inflammatory Responses after Acute Myocardial Infarction in Spontaneous Hypertensive Rats (SHRs) Pharmaceuticals doi: 10.3390/ph17050547 Authors: Pamela Nithzi Bricher Choque Maria Helena Porter Manuella S. Teixeira Humberto Dellê Rosilene Motta Elias Bruno Durante Marina Rascio Henriques Dutra Christine N. Metz Valentin A. Pavlov Fernanda M. Consolim Colombo Background: In this investigation, we explored the effects of pharmacological cholinergic stimulation on cardiac function an ..read more

Pharmaceuticals, Vol. 17, Pages 545: Antibacterial, Anti-Biofilm, and Anti-Inflammatory Properties of Gelatin–Chitosan–Moringa-Biopolymer-Based Wound Dressings towards Staphylococcus aureus and Escherichia coli Pharmaceuticals doi: 10.3390/ph17050545 Authors: Salma Bessalah Asim Faraz Mohamed Dbara Touhami Khorcheni Mohamed Hammadi Daniel Jesuwenu Ajose Shamsaldeen Ibrahim Saeed In contemporary times, the sustained aspiration of bioengineering and biomedical applications is the progressive advancement of materials characterized by biocompatibility and biodegradability. The ..read more

Pharmaceuticals, Vol. 17, Pages 543: In Silico Design of Potential Small-Molecule Antibiotic Adjuvants against Salmonella typhimurium Ortho Acetyl Sulphydrylase Synthase to Address Antimicrobial Resistance Pharmaceuticals doi: 10.3390/ph17050543 Authors: Oluwadunni F. Elebiju Gbolahan O. Oduselu Temitope A. Ogunnupebi Olayinka O. Ajani Ezekiel Adebiyi The inhibition of O-acetyl sulphydrylase synthase isoforms has been reported to represent a promising approach for the development of antibiotic adjuvants. This occurs via the organism developing an unpaired oxidative stress response, causing a r ..read more

Pharmaceuticals, Vol. 17, Pages 544: Evaluating the Safety of Herbal Medicine on Renal Function: A Comprehensive Analysis from Six Randomized Controlled Trials Conducted with Four Formulations from Traditional Korean Medicine Pharmaceuticals doi: 10.3390/ph17050544 Authors: Jin-Yong Joung Chang-Gue Son The growing popularity of herbal medicine raises concerns about potential nephrotoxicity risks, while limited evidence hinders a comprehensive impact assessment. This study aims to investigate the overall risk features of herbal medicine on kidney injury. We conducted a retrospective analysis on ..read more