Pharmaceuticals, Vol. 17, Pages 650: New Thiazolidine-4-One Derivatives as SARS-CoV-2 Main Protease Inhibitors
MDPI » Pharmaceuticals
by Antonella Messore, Paolo Malune, Elisa Patacchini, Valentina Noemi Madia, Davide Ialongo, Merve Arpacioglu, Aurora Albano, Giuseppe Ruggieri, Francesco Saccoliti, Luigi Scipione, Enzo Tramontano, Serena Canton, Angela Corona, Sante Scognamiglio, Annalaura Paulis, Mustapha Suleiman, Helmi Mohammed Al-Maqtari, Fatma Mohamed A. Abid, Sarkar M. A. Kawsar, Murugesan Sankaranarayanan, Roberto Di Santo, Francesca Esposito, Roberta Costi
1d ago
Pharmaceuticals, Vol. 17, Pages 650: New Thiazolidine-4-One Derivatives as SARS-CoV-2 Main Protease Inhibitors Pharmaceuticals doi: 10.3390/ph17050650 Authors: Antonella Messore Paolo Malune Elisa Patacchini Valentina Noemi Madia Davide Ialongo Merve Arpacioglu Aurora Albano Giuseppe Ruggieri Francesco Saccoliti Luigi Scipione Enzo Tramontano Serena Canton Angela Corona Sante Scognamiglio Annalaura Paulis Mustapha Suleiman Helmi Mohammed Al-Maqtari Fatma Mohamed A. Abid Sarkar M. A. Kawsar Murugesan Sankaranarayanan Roberto Di Santo Francesca Esposito Roberta Costi It has been more than four y ..read more
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Pharmaceuticals, Vol. 17, Pages 654: Enhanced Anti-Inflammatory Activity of Tilianin Based on the Novel Amorphous Nanocrystals
MDPI » Pharmaceuticals
by Min Sun, Mengran Guo, Zhongshan He, Yaoyao Luo, Xi He, Chuansheng Huang, Yong Yuan, Yunli Zhao, Xiangrong Song, Xinchun Wang
1d ago
Pharmaceuticals, Vol. 17, Pages 654: Enhanced Anti-Inflammatory Activity of Tilianin Based on the Novel Amorphous Nanocrystals Pharmaceuticals doi: 10.3390/ph17050654 Authors: Min Sun Mengran Guo Zhongshan He Yaoyao Luo Xi He Chuansheng Huang Yong Yuan Yunli Zhao Xiangrong Song Xinchun Wang Tilianin (Til), a flavonoid glycoside, is well-known for its therapeutic promise in treating inflammatory disorders. Its poor water solubility and permeability limit its clinical applicability. In order to overcome these restrictions, an antisolvent precipitation and ultrasonication technique was used to pr ..read more
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Pharmaceuticals, Vol. 17, Pages 652: Progress and Innovative Combination Therapies in Trop-2-Targeted ADCs
MDPI » Pharmaceuticals
by Yizhi Jiang, Haiting Zhou, Junxia Liu, Wentao Ha, Xiaohui Xia, Jiahao Li, Tengfei Chao, Huihua Xiong
1d ago
Pharmaceuticals, Vol. 17, Pages 652: Progress and Innovative Combination Therapies in Trop-2-Targeted ADCs Pharmaceuticals doi: 10.3390/ph17050652 Authors: Yizhi Jiang Haiting Zhou Junxia Liu Wentao Ha Xiaohui Xia Jiahao Li Tengfei Chao Huihua Xiong Precise targeting has become the main direction of anti-cancer drug development. Trophoblast cell surface antigen 2 (Trop-2) is highly expressed in different solid tumors but rarely in normal tissues, rendering it an attractive target. Trop-2-targeted antibody-drug conjugates (ADCs) have displayed promising efficacy in treating diverse solid tumors ..read more
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Pharmaceuticals, Vol. 17, Pages 651: The Antagonistic and Synergistic Role of Fe3+ Compounds in Chemo- and Electrochemotherapy in Human Colon Cancer In Vitro
MDPI » Pharmaceuticals
by Wojciech Szlasa, Wiktoria Mazurek, Anna Szewczyk, Nina Rembiałkowska, Joanna Tunikowska, Julita Kulbacka
1d ago
Pharmaceuticals, Vol. 17, Pages 651: The Antagonistic and Synergistic Role of Fe3+ Compounds in Chemo- and Electrochemotherapy in Human Colon Cancer In Vitro Pharmaceuticals doi: 10.3390/ph17050651 Authors: Wojciech Szlasa Wiktoria Mazurek Anna Szewczyk Nina Rembiałkowska Joanna Tunikowska Julita Kulbacka Colon cancer (CC) management includes surgery, radio- and chemotherapy based on treatment with 5-fluorouracil (5-FU) or its derivatives. However, its application is limited to low-grade carcinomas. Thus, much research has been conducted to introduce new techniques and drugs to the therapy. CC ..read more
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Pharmaceuticals, Vol. 17, Pages 653: Testing of Anti-EMT, Anti-Inflammatory and Antibacterial Activities of 2′,4′-Dimethoxychalcone
MDPI » Pharmaceuticals
by Peiling Zhao, Mengzhen Xu, Kai Gong, Kaihui Lu, Chen Ruan, Xin Yu, Jiang Zhu, Haixing Guan, Qingjun Zhu
1d ago
Pharmaceuticals, Vol. 17, Pages 653: Testing of Anti-EMT, Anti-Inflammatory and Antibacterial Activities of 2′,4′-Dimethoxychalcone Pharmaceuticals doi: 10.3390/ph17050653 Authors: Peiling Zhao Mengzhen Xu Kai Gong Kaihui Lu Chen Ruan Xin Yu Jiang Zhu Haixing Guan Qingjun Zhu Chalcone (1,3-diaryl-2-propen-1-one) is an α, β-unsaturated ketone that serves as an active constituent or precursor of numerous natural substances, exhibiting a broad spectrum of pharmacological effects. In this study, the classical Claisen–Schmidt condensation ..read more
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Pharmaceuticals, Vol. 17, Pages 655: Exploring the Potential Biological Activities of Pyrazole-Based Schiff Bases as Anti-Diabetic, Anti-Alzheimer’s, Anti-Inflammatory, and Cytotoxic Agents: In Vitro Studies with Computational Predictions
MDPI » Pharmaceuticals
by Ahmed M. Naglah, Abdulrahman A. Almehizia, Asma S. Al-Wasidi, Amirah Senaitan Alharbi, Mohammed H. Alqarni, Ashraf S. Hassan, Wael M. Aboulthana
1d ago
Pharmaceuticals, Vol. 17, Pages 655: Exploring the Potential Biological Activities of Pyrazole-Based Schiff Bases as Anti-Diabetic, Anti-Alzheimer’s, Anti-Inflammatory, and Cytotoxic Agents: In Vitro Studies with Computational Predictions Pharmaceuticals doi: 10.3390/ph17050655 Authors: Ahmed M. Naglah Abdulrahman A. Almehizia Asma S. Al-Wasidi Amirah Senaitan Alharbi Mohammed H. Alqarni Ashraf S. Hassan Wael M. Aboulthana In this innovative research, we aim to reveal pyrazole-based Schiff bases as new multi-target agents. In this context, we re-synthesized three sets of pyrazole-bas ..read more
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Pharmaceuticals, Vol. 17, Pages 644: Extracellular Matrix Stiffness-Induced Mechanotransduction of Capillarized Liver Sinusoidal Endothelial Cells
MDPI » Pharmaceuticals
by Qingjuan Wu, Quanmei Sun, Qiang Zhang, Ning Wang, Wenliang Lv, Dong Han
2d ago
Pharmaceuticals, Vol. 17, Pages 644: Extracellular Matrix Stiffness-Induced Mechanotransduction of Capillarized Liver Sinusoidal Endothelial Cells Pharmaceuticals doi: 10.3390/ph17050644 Authors: Qingjuan Wu Quanmei Sun Qiang Zhang Ning Wang Wenliang Lv Dong Han The mechanobiological response mechanism of the fenestrae of liver sinusoidal endothelial cells (LSECs) to the physical stiffness of the extracellular matrix (ECM) remains unclear. We investigated how the mechanical properties of their substrates affect the LSECs’ fenestrae by the nitric oxide (NO)-dependent pathway and h ..read more
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Pharmaceuticals, Vol. 17, Pages 643: Exploring the Mechanism of Fufang Danshen Tablet against Atherosclerosis by Network Pharmacology and Experimental Validation
MDPI » Pharmaceuticals
by Yuling Liu, Weiwei Su, Peibo Li, Xuan Zeng, Yuying Zheng, Yonggang Wang, Wei Peng, Hao Wu
2d ago
Pharmaceuticals, Vol. 17, Pages 643: Exploring the Mechanism of Fufang Danshen Tablet against Atherosclerosis by Network Pharmacology and Experimental Validation Pharmaceuticals doi: 10.3390/ph17050643 Authors: Yuling Liu Weiwei Su Peibo Li Xuan Zeng Yuying Zheng Yonggang Wang Wei Peng Hao Wu Atherosclerosis is the main pathological basis of cardiovascular diseases (CVDs). Fufang Danshen Tablet (FDT) is a traditional Chinese medicine that has been clinically used to treat CVDs for more than 40 years. Nevertheless, owing to the complexity of the ingredients, the pharmacological mechanism of FDT ..read more
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Pharmaceuticals, Vol. 17, Pages 645: HGFK1 Enhances the Anti-Tumor Effects of Angiogenesis Inhibitors via Inhibition of CD90+ CSCs in Hepatocellular Carcinoma
MDPI » Pharmaceuticals
by Tao Li, Ling Liu, Li Li, Xiaoxuan Yao, Xiaoyuan Hu, Jiaxing Cheng, Zhenpu Chen, Jiyin Guo, Ruilei Li, Chunlei Ge, Marie Chia-Mi Lin, Hong Yao
2d ago
Pharmaceuticals, Vol. 17, Pages 645: HGFK1 Enhances the Anti-Tumor Effects of Angiogenesis Inhibitors via Inhibition of CD90+ CSCs in Hepatocellular Carcinoma Pharmaceuticals doi: 10.3390/ph17050645 Authors: Tao Li Ling Liu Li Li Xiaoxuan Yao Xiaoyuan Hu Jiaxing Cheng Zhenpu Chen Jiyin Guo Ruilei Li Chunlei Ge Marie Chia-Mi Lin Hong Yao The combination of anti-angiogenesis agents with immune-checkpoint inhibitors is a promising treatment for patients with advanced hepatocellular carcinoma (HCC); however, therapeutic resistance caused by cancer stem cells present in tumor microenvironments rema ..read more
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Pharmaceuticals, Vol. 17, Pages 646: Hive Products: Composition, Pharmacological Properties, and Therapeutic Applications
MDPI » Pharmaceuticals
by Roberto Bava, Fabio Castagna, Carmine Lupia, Giusi Poerio, Giovanna Liguori, Renato Lombardi, Maria Diana Naturale, Rosa Maria Bulotta, Vito Biondi, Annamaria Passantino, Domenico Britti, Giancarlo Statti, Ernesto Palma
2d ago
Pharmaceuticals, Vol. 17, Pages 646: Hive Products: Composition, Pharmacological Properties, and Therapeutic Applications Pharmaceuticals doi: 10.3390/ph17050646 Authors: Roberto Bava Fabio Castagna Carmine Lupia Giusi Poerio Giovanna Liguori Renato Lombardi Maria Diana Naturale Rosa Maria Bulotta Vito Biondi Annamaria Passantino Domenico Britti Giancarlo Statti Ernesto Palma Beekeeping provides products with nutraceutical and pharmaceutical characteristics. These products are characterized by abundance of bioactive compounds. For different reasons, honey, royal jelly, propolis, venom, and pol ..read more
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