Cancers, Vol. 16, Pages 1785: Programmed Death Ligand 1 Expression in Circulating Tumor Cells as a Predictor and Monitor of Response to Atezolizumab plus Bevacizumab Treatment in Patients with Hepatocellular Carcinoma Cancers doi: 10.3390/cancers16091785 Authors: Takuto Nosaka Yosuke Murata Yu Akazawa Tomoko Tanaka Kazuto Takahashi Tatsushi Naito Hidetaka Matsuda Masahiro Ohtani Yoshiaki Imamura Yasunari Nakamoto There remains no reliable biomarker of therapeutic efficacy in hepatocellular carcinoma (HCC) for the PD-L1 inhibitor atezolizumab and bevacizumab (Atezo/Bev). Circulating tumor cells ..read more

Cancers, Vol. 16, Pages 1786: Phytochemical Modulation of Ion Channels in Oncologic Symptomatology and Treatment Cancers doi: 10.3390/cancers16091786 Authors: Rohan Rao Caroline Mohammed Lise Alschuler Daniel A. Pomeranz Krummel Soma Sengupta Modern chemotherapies offer a broad approach to cancer treatment but eliminate both cancer and non-cancer cells indiscriminately and, thus, are associated with a host of side effects. Advances in precision oncology have brought about new targeted therapeutics, albeit mostly limited to a subset of patients with an actionable mutation. They too come with si ..read more

Cancers, Vol. 16, Pages 1778: The Diagnostic Performance of 2-[18F]FDG PET/CT in Identifying Richter Transformation in Chronic Lymphocytic Leukemia: An Updated Systematic Review and Bivariate Meta-Analysis Cancers doi: 10.3390/cancers16091778 Authors: Domenico Albano Alessio Rizzo Manuela Racca Barbara Muoio Francesco Bertagna Giorgio Treglia Richter transformation is a rare phenomenon characterized by the transformation of cell chronic lymphocytic leukemia (CLL) into a more aggressive lymphoma variant. The early identification of CLLs with a high risk of RT is fundamental. In this field, 2-de ..read more

Cancers, Vol. 16, Pages 1779: Opaganib Downregulates N-Myc Expression and Suppresses In Vitro and In Vivo Growth of Neuroblastoma Cells Cancers doi: 10.3390/cancers16091779 Authors: Lynn W. Maines Staci N. Keller Ryan A. Smith Randy S. Schrecengost Charles D. Smith Neuroblastoma (NB), the most common cancer in infants and the most common solid tumor outside the brain in children, grows aggressively and responds poorly to current therapies. We have identified a new drug (opaganib, also known as ABC294640) that modulates sphingolipid metabolism by inhibiting the synthesis of sphingosine 1-phosph ..read more

Cancers, Vol. 16, Pages 1780: How Immunotherapy Has Redefined the Treatment Paradigm of Metastatic or Locally Advanced Muscle-Invasive Urothelial Bladder Carcinoma Cancers doi: 10.3390/cancers16091780 Authors: Mathieu Larroquette Félix Lefort Charlotte Domblides Luc Héraudet Grégoire Robert Alain Ravaud Marine Gross-Goupil In the past decade, the therapeutic arsenal for metastatic bladder cancer has expanded considerably, with the development of immune checkpoint inhibitors (ICIs), antibody–drug conjugates such as enfortumab vedotin, and anti-fibroblast growth factor receptor age ..read more

Cancers, Vol. 16, Pages 1781: Amplification of Hippo Signaling Pathway Genes Is Governed and Implicated in the Serous Subtype-Specific Ovarian Carcino-Genesis Cancers doi: 10.3390/cancers16091781 Authors: Karthik Balakrishnan Yuanhong Chen Jixin Dong Among women, ovarian cancer ranks as the fifth most common cause of cancer-related deaths. This study examined the impact of Hippo signaling pathway on ovarian carcinogenesis. Therefore, the signatures related to Hippo signaling pathway were derived from the molecular signatures database (MSigDB) and were used for further analysis. The Z score-bas ..read more

Cancers, Vol. 16, Pages 1782: Spinal Intradural Tumor Resection via Long-Segment Approaches and Clinical Long-Term Follow-Up Cancers doi: 10.3390/cancers16091782 Authors: Laura Dieringer Lea Baumgart Laura Schwieren Jens Gempt Maria Wostrack Bernhard Meyer Vicki M. Butenschoen Introduction: Spinal intradural tumors account for 15% of all CNS tumors. Typical tumor entities include ependymomas, astrocytomas, meningiomas, and neurinomas. In cases of multiple affected segments, extensive approaches may be necessary to achieve the gold standard of complete tumor resection. Methods: We performed a b ..read more

Cancers, Vol. 16, Pages 1783: Two-Year-Span Breast Cancer Screening Uptake in Japan after the COVID-19 Pandemic and Its Association with the COVID-19 Vaccination Cancers doi: 10.3390/cancers16091783 Authors: Aminu Kende Abubakar Yudai Kaneda Akihiko Ozaki Hiroaki Saito Michio Murakami Daisuke Hori Kenji Gonda Masaharu Tsubokura Takahiro Tabuchi There is limited information on whether the COVID-19 pandemic was associated with decreased breast cancer screening uptake and if COVID-19 vaccination was associated with an increase in screening uptake. Our study explored the uptake of breast cancer sc ..read more

Cancers, Vol. 16, Pages 1784: Hypnosis-Assisted Awake Craniotomy for Eloquent Brain Tumors: Advantages and Pitfalls Cancers doi: 10.3390/cancers16091784 Authors: Giulia Cossu Alberto Vandenbulcke Sonia Zaccarini John G. Gaudet Andreas F. Hottinger Nina Rimorini Arnaud Potie Valerie Beaud Ursula Guerra-Lopez Roy T. Daniel Chantal Berna Mahmoud Messerer Background: Awake craniotomy (AC) is recommended for the resection of tumors in eloquent areas. It is traditionally performed under monitored anesthesia care (MAC), which relies on hypnotics and opioids. Hypnosis-assisted AC (HAAC) is an emerging ..read more

Cancers, Vol. 16, Pages 1777: “Seeing Is Believing”: Additive Utility of 68Ga-PSMA-11 PET/CT in Prostate Cancer Diagnosis Cancers doi: 10.3390/cancers16091777 Authors: Joel Chin Yu Guang Tan Alvin Lee Tze Kiat Ng Ruoyu Shi Charlene Yu Lin Tang Sue Ping Thang Jeffrey Kit Loong Tuan Christopher Wai Sam Cheng Kae Jack Tay Henry Sun Sien Ho Hung-Jen Wang Peter Ka-Fung Chiu Jeremy Yuen-Chun Teoh Winnie Wing-Chuen Lam Yan Mee Law John Shyi Peng Yuen Kenneth Chen Widespread adoption of mpMRI has led to a decrease in the number of patients requiring prostate biopsies. 68Ga-PSMA-11 ..read more