Genes, Vol. 15, Pages 500: Biallelic NDUFA4 Deletion Causes Mitochondrial Complex IV Deficiency in a Patient with Leigh Syndrome Genes doi: 10.3390/genes15040500 Authors: Doriana Misceo Petter Strømme Fatemeh Bitarafan Maninder Singh Chawla Ying Sheng Sandra Monica Bach de Courtade Lars Eide Eirik Frengen Oxidative phosphorylation involves a complex multi-enzymatic mitochondrial machinery critical for proper functioning of the cell, and defects herein cause a wide range of diseases called “primary mitochondrial disorders” (PMDs). Mutations in about 400 nuclear and 3 ..read more

Genes, Vol. 15, Pages 495: Heritability of Gene Expression Measured from Peripheral Blood in Older Adults Genes doi: 10.3390/genes15040495 Authors: Sri C. Kanchibhotla Karen A. Mather Nicola J. Armstrong Liliana G. Ciobanu Bernhard T. Baune Vibeke S. Catts Peter R. Schofield Julian N. Trollor David Ames Perminder S. Sachdev Anbupalam Thalamuthu The contributions of genetic variation and the environment to gene expression may change across the lifespan. However, few studies have investigated the heritability of blood gene expression in older adults. The current study therefore aimed to investig ..read more

Genes, Vol. 15, Pages 497: Association of CYP3A4-392A/G, CYP3A5-6986A/G, and ABCB1-3435C/T Polymorphisms with Tacrolimus Dose, Serum Concentration, and Biochemical Parameters in Mexican Patients with Kidney Transplant Genes doi: 10.3390/genes15040497 Authors: Edith Viridiana Alatorre-Moreno Ana Miriam Saldaña-Cruz Edsaúl Emilio Pérez-Guerrero María Cristina Morán-Moguel Betsabé Contreras-Haro David Alejandro López-de La Mora Ingrid Patricia Dávalos-Rodríguez Alejandro Marín-Medina Alicia Rivera-Cameras Luz-Ma Adriana Balderas-Peña José Juan Gómez-Ramos Laura Cortés-Sanabria Mario Salazar-Páram ..read more

Genes, Vol. 15, Pages 496: Neurofilaments in Sporadic and Familial Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis Genes doi: 10.3390/genes15040496 Authors: Pashtun Shahim Gina Norato Ninet Sinaii Henrik Zetterberg Kaj Blennow Leighton Chan Christopher Grunseich Background: Neurofilament proteins have been implicated to be altered in amyotrophic lateral sclerosis (ALS). The objectives of this study were to assess the diagnostic and prognostic utility of neurofilaments in ALS. Methods: Studies were conducted in electronic databases (PubMed/MEDLINE, Embase, Web of Science, a ..read more

Genes, Vol. 15, Pages 498: Comparison of Fecal MicroRNA Isolation Using Various Total RNA Isolation Kits Genes doi: 10.3390/genes15040498 Authors: Theresa Lederer Noam M. Hipler Cosima Thon Juozas Kupcinskas Alexander Link Fecal specimens have long been regarded as promising sources for gastrointestinal cancer screening and have, thus, been extensively investigated in biomarker research. MicroRNAs (miRNAs) are small, non-coding RNA molecules involved in regulating various biological processes. They are commonly dysregulated during tumor development and exhibit differential expression in feces ..read more

Genes, Vol. 15, Pages 499: Proteomic Analysis of Lysine Acetylation and Succinylation to Investigate the Pathogenicity of Virulent Pseudomonas syringae pv. tomato DC3000 and Avirulent Line Pseudomonas syringae pv. tomato DC3000 avrRpm1 on Arabidopsis thaliana Genes doi: 10.3390/genes15040499 Authors: Ding Liu Yang Zhao Wen Yang Zhang Pseudomonas syringae pv. tomato DC3000 (Pst DC3000) is able to infect many economically important crops and thus causes substantial losses in the global agricultural economy. Pst DC3000 can be divided into virulent lines and avirulent lines. For instance, the path ..read more

Genes, Vol. 15, Pages 492: Shedding a Light on Dark Genes: A Comparative Expression Study of PRR12 Orthologues during Zebrafish Development Genes doi: 10.3390/genes15040492 Authors: Alessia Muscò Davide Martini Matteo Digregorio Vania Broccoli Massimiliano Andreazzoli Haploinsufficiency of the PRR12 gene is implicated in a human neuro-ocular syndrome. Although identified as a nuclear protein highly expressed in the embryonic mouse brain, PRR12 molecular function remains elusive. This study explores the spatio-temporal expression of zebrafish PRR12 co-orthologs, prr12a and prr12b, as a first st ..read more

Genes, Vol. 15, Pages 493: FOXP3: A Player of Immunogenetic Architecture in Lung Cancer Genes doi: 10.3390/genes15040493 Authors: Iwona Ziółkowska-Suchanek Magdalena Żurawek The transcription factor forkhead box protein 3 (FOXP3) is considered to be a prominent component of the immune system expressed in regulatory T cells (Tregs). Tregs are immunosuppressive cells that regulate immune homeostasis and self-tolerance. FOXP3 was originally thought to be a Tregs-specific molecule, but recent studies have pinpointed that FOXP3 is expressed in a diversity of benign tumors and carcinomas. The vast m ..read more

Genes, Vol. 15, Pages 494: Identification of Key Genes and Imbalanced SNAREs Assembly in the Comorbidity of Polycystic Ovary Syndrome and Depression Genes doi: 10.3390/genes15040494 Authors: Yi Cao Weijing Wang Xuxia Song Qian Wen Jing Xie Dongfeng Zhang Background: Women with polycystic ovary syndrome (PCOS) have increased odds of concurrent depression, indicating that the relationship between PCOS and depression is more likely to be comorbid. However, the underlying mechanism remains unclear. Here, we aimed to use bioinformatic analysis to screen for the genetic elements shared between PCOS ..read more

Genes, Vol. 15, Pages 491: Association of Gene Polymorphisms with Normal Tension Glaucoma: A Systematic Review and Meta-Analysis Genes doi: 10.3390/genes15040491 Authors: Lijie Pan Jian Wu Ningli Wang Background: Normal tension glaucoma (NTG) is becoming a more and more serious problem, especially in Asia. But the pathological mechanisms are still not illustrated clearly. We carried out this research to uncover the gene polymorphisms with NTG. Methods: We searched in Web of Science, Embase, Pubmed and Cochrane databases for qualified case-control studies investigating the association between s ..read more