Is Gene Therapy Nearing a Tipping Point?
GEN News
by Kathy Vuksanaj
20h ago
REGISTER NOW Broadcast Date:  Wednesday, April 24, 2024 Time:  9:00 am PDT, 12:00 pm EDT, 18:00 CEST Gene therapy has undergone a renaissance in recent years, with several drugs offering beneficial, even life-saving treatments, now approved by the FDA. One example was reported earlier this year, with the progress made by two separate research teams working on gene therapy programs targeting hearing loss. And the FDA has stated that they expect an increase in the number of authorizations of gene therapy treatments over the next few years. But getting gene therapies into patient ..read more
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Launch of Nvelop Therapeutics for Delivery of Genetic Cargo, AACR Recap
GEN News
by Kathy Vuksanaj
21h ago
Episode 17 (April 12, 2024): This week, the GEN editors discuss the launch of Nvelop Therapeutics, a new start-up leveraging approaches developed by gene editing pioneers David Liu, PhD, and J. Keith Joung, MD, PhD, to advance delivery of genetic cargo. The GEN editors also recap highlights from the American Association for Cancer Research (AACR) annual meeting held in San Diego, California. Featuring Uduak Thomas (Senior Editor, GEN), Alex Philippidis (Senior Business Editor, GEN), Julianna LeMieux, PhD (Deputy Editor-in-Chief, GEN), and Jonathan Grinstein, PhD (Senior Editor, GEN ..read more
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Detecting Growing Tumors through Changes in the Plasma Proteome
GEN News
by Kathy Vuksanaj
1d ago
REGISTER NOW Broadcast Date:  Monday, April 22, 2024 Time:  8:00 am PDT, 11:00 am EDT, 17:00 CEST For most malignancies, early tumor detection is crucial, as it expands treatment options, reduces metastases, and ultimately improves survival rates. Despite clear clinical appeal, early detection remains a considerable diagnostic challenge since small masses of tumors often remain asymptomatic and are difficult to discern from normal tissue by imaging methods. In this GEN webinar, Nebojsa Janjic, PhD, will discuss the need for a reliable blood-based screening method cap ..read more
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Fujifilm Invests Additional $1.2 Billion to Expand its North Carolina CDMO
GEN News
by John Sterling
1d ago
Fujifilm invested $1.2 billion in its large-scale cell culture CDMO business to further expand the planned Fujifilm Diosynth Biotechnologies end-to-end bio-manufacturing facility in Holly Springs, NC. The total investment in the facility now totals over $3.2 billion. The new investment will add 8 x 20,000 liters mammalian cell culture bioreactors by 2028, to the already planned 8 x 20,000 L for bulk drug substance as part of the initial investment. This new facility allows for flexibility to expand with additional bioreactors to accommodate new projects to meet the emerging needs of partn ..read more
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AI Screening of Pediatric Cancers Improves Treatment Outcomes
GEN News
by Corinna Singleman, PhD
1d ago
Researchers at Florida International University and First Ascent Biomedical have used an artificial intelligence (AI)-powered, functional precision medicine (FPM) platform to identify unique therapeutic treatment options for children with relapsed cancer diagnoses. They published their study, “Feasibility of Functional Precision Medicine for Guiding Treatment of Relapsed or Refractory Pediatric Cancers,” in Nature Medicine. “Children with rare, relapsed, or refractory cancers are often faced with limited treatment options and few predictive biomarkers that can enable personalized treatment rec ..read more
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Dotmatics’ Luma Lab Connect Automates Data Flow For Drug Discovery Laboratories
GEN News
by Uduak Thomas
2d ago
Connectivity between laboratory instruments is crucial for capturing large quantities of multimodal data generated during the drug discovery and development process. With the launch of its newest product, Luma Lab Connect, scientific software provider Dotmatics aims to help drug developers extract data from all of their instruments in a centralized and standardized manner for downstream analysis and interpretation.   A primary benefit of Luma Lab Connect is its ability to automate data flow from lab instruments in real-time in a way that protects the integrity and reliability of expe ..read more
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Psychosis Development Linked to Brain’s Filter/Predictor Mechanisms
GEN News
by Sophia Ktori
2d ago
A Stanford Medicine-led study has found that there are two key systems malfunctioning in the brains of people with psychosis. One is a “filter” that directs attention toward important external events and internal thoughts, and the other a “predictor” composed of pathways that anticipate rewards. The team used a type of machine learning algorithm called a spatiotemporal deep neural network to analyze brain scan data from children, teens, and young adults with a rare genetic disease called 22q11.2 deletion syndrome (22q11.2DS) who experience psychosis, as well as from individuals with psychosis ..read more
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Novel Insights into RNA Modification in HIV-1 Revealed
GEN News
by Christina Jackson
2d ago
Researchers at the Ohio State University report they have settled a matter of scientific debate. In a new study, the researchers discovered a chemical modification in the HIV-1 RNA genome that is now confirmed to be key to the virus’s ability to survive and thrive after infecting host cells. Their findings are published in Nature Microbiology in an article titled, “Single-molecule epitranscriptomic analysis of full-length HIV-1 RNAs reveals functional roles of site-specific m6As.” “Although the significance of chemical modifications on RNA is acknowledged, the evolutionary benefits and sp ..read more
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Can Organoids Unlock the Pathology of Traumatic Brain Injuries?
GEN News
by Kathy Vuksanaj
2d ago
REGISTER NOW Broadcast Date:  Friday, May 17, 2024 Time:  8:00 am PDT, 11:00 am EDT, 17:00 CEST About five million people in the United States alone live with traumatic brain injuries (TBIs). These injuries can quadruple the risk of developing Alzheimer’s disease, and other dementias, and increase the likelihood of developing neurodegenerative diseases such as amyotrophic lateral sclerosis. Rodent models of TBI have clarified some aspects of these injuries; however, most treatment approaches have had limited success because some of the details of the underlying mechanisms ..read more
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Earli Detection: “Synthetic” Biomarkers Light Up Hidden Malignant Cancers
GEN News
by Jonathan D. Grinstein, PhD
2d ago
The late Sanjiv (Sam) Gambhir, MD, PhD, spent his life fighting cancer. A pioneer in cancer imaging, Gambhir helped develop Positron emission tomography (PET) reporter gene technology. Gambhir, a distinguished professor at the Stanford University School of Medicine and an advisor to numerous companies, was never content with the sensitivity of cancer detection technologies when it came to finding early-stage cancers. With 70 percent of all cancers discovered at Stage 3 or 4, waiting for symptoms is usually too late, with a five-year survival rate of only 25 percent. After losing his son Milan ..read more
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