Nature Neuroscience, Published online: 10 April 2024; doi:10.1038/s41593-024-01619-1 Using human iPSC-derived and mouse neurons, this study demonstrates that mRNA transport on lysosome-related vesicles is critical for the maintenance of axonal homeostasis and that its failure causes axonal degeneration ..read more

Nature Neuroscience, Published online: 10 April 2024; doi:10.1038/s41593-024-01629-z The study of the female brain during pregnancy and motherhood is gaining traction, and holds the potential to address the unmet needs of millions of women worldwide. Here we highlight the most pressing gaps in this field. Filling these knowledge gaps will require two paths forward: focused longitudinal studies that deeply characterize individuals, and collaborative initiatives that build large-scale international databases ..read more

Nature Neuroscience, Published online: 09 April 2024; doi:10.1038/s41593-024-01616-4 RNA alternative splicing is involved in determining cell identity, but a comprehensive molecular map is missing. Here, the authors provide a human and mouse brain atlas of transcript isoforms linking them to cellular identity, brain regions and development stages ..read more

Nature Neuroscience, Published online: 09 April 2024; doi:10.1038/s41593-024-01617-3 In the first comprehensive mRNA isoform atlas of the developing and adult mouse brain, we discover that region and age influence the isoform repertoire of cell subtypes. We link peak cell type regulation to the critical development period and report attenuated levels in adulthood ..read more

Nature Neuroscience, Published online: 08 April 2024; doi:10.1038/s41593-024-01615-5 Precise profiling of dendritic RNA regulation reveals how neuronal depolarization leads to ribosome switching onto short upstream open reading frames and new coding sequences to acutely modulate local protein synthesis ..read more

Nature Neuroscience, Published online: 08 April 2024; doi:10.1038/s41593-024-01623-5 Pushing the bounds on dimensionality ..read more

Nature Neuroscience, Published online: 08 April 2024; doi:10.1038/s41593-024-01622-6 HDAC3 stokes microglia in stroke ..read more

Nature Neuroscience, Published online: 08 April 2024; doi:10.1038/s41593-024-01621-7 Restoring sensation to prosthetics ..read more

Nature Neuroscience, Published online: 03 April 2024; doi:10.1038/s41593-024-01612-8 How astrocytes can integrate information is incompletely understood. Here the authors show that locus coeruleus-controlled calcium signals in hippocampal astrocytes propagating from their processes to their soma are involved in the information integration upon salient events ..read more

Nature Neuroscience, Published online: 02 April 2024; doi:10.1038/s41593-024-01594-7 Silva et al. definitively establish climbing fiber-driven complex spike events as essential instructive signals for associative cerebellar learning while also revealing unexpected features of optogenetic manipulation ..read more