The objective of this study was to identify the correlation between actin‐related protein 2/3 complex subunit 4 (ARPC4) and lymph node metastasis, and to examine the role of ARPC4 in the invasive migration of T24 bladder cancer cells. Finally, we found that the expression of ARPC4, as a risk factor, was associated with lymphatic metastasis and was elevated in bladder cancer tissues when compared with normal bladder tissues. Besides, inhibition of ARPC4 expression significantly attenuated bladder cancer cell proliferation, migration, and invasion, possibly as a consequence of defects in pseudop ..read more

Journal of Cellular Biochemistry, Volume 121, Issue 1, Page 1-6, January 2020 ..read more

This paper investigates phagocytosis when the two major opsonic receptors are engaged. Binding, signaling, and actin remodeling are examined to understand how macrophages internalize dual‐opsonized targets, compared with when a single receptor is involved. Abstract Our current understanding of phagocytosis is largely derived from studies of individual receptor‐ligand interactions and their downstream signaling pathways. Because phagocytes are exposed to a variety of ligands on heterogeneous target particles in vivo, it is important to observe the engagement of multiple receptors simultaneous ..read more

We showed that miR‐605‐5p plays a tumor‐suppressor role in non–small‐cell lung cancer (NSCLC). It functions mainly by targeting tumor necrosis factor α‐induced protein 3 (TNFAIP3) expression. These findings suggest a specific mechanism of NSCLC progression and suggest miR‐605‐5p as a potential therapeutic target for NSCLC. Abstract Lung cancer is an significant cause of death worldwide, and non–small‐cell lung cancer (NSCLC) is the most common type of lung cancer. MicroRNAs (miRNAs) have been identified to play key roles in NSCLC development. Recently, it has been reported that miR‐605‐5p is ..read more

Abstract Background The small‐molecule nutlin‐3 was found to be an effective therapeutic compound and p53 activator, and acts as a murine double minute 2 antagonist, although these findings need to be clinically confirmed. The essential components of the bone marrow include mesenchymal stem cells (MSCs), which play a key role in protecting, regenerating, and proliferating hematopoietic stem cells (HSCs). This feature is vital for HSC after exposure to myelotoxic anticancer agents; nevertheless, the effects of nutlin‐3 on MSCs remain to be disclosed. The present research study was conducted to ..read more

miR‐302b‐3p accelerates fibroblast senescence. miR‐302b‐3p accelerates senescence via direct targeting JNK2. Abstract Numbers of emerging evidence suggest that variable microRNA (miRNA) expression facilitates the aging process. In this study, we distinguished aberrant miRNA expression in aged skin and explored the biological functions and potential mechanism of upregulated miR‐302b‐3p. At first, miRNA microarray analysis was examined to explore miRNA expression profiling in the skin of aging mice model by D‐galactose (d‐gal) injection. We identified 29 aberrant miRNAs in aged mice skin. Next ..read more

Pancreatic stellate cells augment the glucose‐stimulated insulin secretion from Min6 cells, with no possible involvement of IL6‐induced PLC‐IP3 ‐dependent pathway. Abstract Pancreatic stellate cells (PSCs) secrete various factors, which can influence the β‐cell function. The identification of stellate cell infiltration into the islets in pancreatic diseases suggests possible existence of cross‐talk between these cells. To elucidate the influence of PSCs on β‐cell function, mouse PSCs were cocultured with Min6 cells using the Transwell inserts. Glucose‐stimulated insulin secretion from Min6 ..read more

We constructed lncRNA‐miRNA‐mRNA network in gastric cancer and identified the key nodes based on complex network theory. Functional enrichment analysis and survival analysis of key genes in network related to key nodes were performed. The key factors in gastric cancer regulatory network can provide new insights into understanding the pathogenesis of gastric cancer and the diagnosis and treatment of gastric cancer. Abstract The oncogenesis and progression of gastric cancer are closely correlated with the complex regulatory relationships among messenger RNA (mRNA), long noncoding RNA (lncRNA ..read more

Large intergenic noncoding RNA regulator of reprogramming (Linc‐RoR) promoted proliferation, migration, and invasion of pancreatic cancer cells by activating the Hippo/YAP pathway. YAP might be an underlying target of Linc‐RoR and mediate EMT in pancreatic cancer (PC); thus, Linc‐RoR might be a very meaningful biomarker for PC Abstract Large intergenic noncoding RNA regulator of reprogramming (Linc‐RoR) was first identified as a regulator to increase the emergence of induced pluripotent stem cells through reprogramming differentiated cells and is abnormal expression in a variety of malignan ..read more

miR‐4319 was found to be downregulated in thyroid cancer cells and its overexpression inhibited proliferation, migration, and epithelial‐to‐mesenchymal transition (EMT) in thyroid cancer. miR‐4319 was found to target SMAD‐specific E3 ubiquitin protein ligase 1 (SMURF1) in thyroid cancer cells. miR‐4319 inhibited the stabilization of SMURF1 messenger RNA by competing with fused in sarcoma to target SMURF1. miR‐4319 inhibited cell proliferation, migration, and EMT through SMURF1 in thyroid cancer. Abstract Thyroid cancer, a common type of endocrine system cancer, has witnessed rising incidence ..read more