Digestive Disease Week 2024
Nature Reviews Gastroenterology & Hepatology
by Katrina Ray
2d ago
Nature Reviews Gastroenterology & Hepatology, Published online: 17 June 2024; doi:10.1038/s41575-024-00954-9 Digestive Disease Week 2024 ..read more
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Unlocking the promise of RAS inhibition in pancreatic cancer
Nature Reviews Gastroenterology & Hepatology
by Saurav D. Haldar, Nilofer S. Azad
5d ago
Nature Reviews Gastroenterology & Hepatology, Published online: 14 June 2024; doi:10.1038/s41575-024-00951-y The advent of next-generation RAS inhibitors brings renewed optimism to the care of patients with pancreatic cancer after decades of failure for novel therapeutics. A recent study highlights the potent antitumour activity of the multi-selective RAS(ON) inhibitor RMC-7977 across a spectrum of preclinical pancreatic cancer models ..read more
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Next generation of gastrointestinal electrophysiology devices
Nature Reviews Gastroenterology & Hepatology
by Haitao Liu, Siheng Sean You, Zhigang Gao, Ning Hu, Yunlong Zhao
5d ago
Nature Reviews Gastroenterology & Hepatology, Published online: 14 June 2024; doi:10.1038/s41575-024-00952-x This Comment reviews the evolution from early electrophysiological studies to advanced diagnostic tools, highlighting the challenges and innovations shaping the future of gastrointestinal diagnostics ..read more
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Intermittent fasting for NASH and HCC in mice
Nature Reviews Gastroenterology & Hepatology
by Jordan Hindson
5d ago
Nature Reviews Gastroenterology & Hepatology, Published online: 14 June 2024; doi:10.1038/s41575-024-00953-w Intermittent fasting for NASH and HCC in mice ..read more
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Designing clinical trials to address alcohol use and alcohol-associated liver disease: an expert panel Consensus Statement
Nature Reviews Gastroenterology & Hepatology
by Brian P. Lee, Katie Witkiewitz, Jessica Mellinger, Frank A. Anania, Ramon Bataller, Thomas G. Cotter, Brenda Curtis, Srinivasan Dasarathy, Kelly S. DeMartini, Ivan Diamond, Nancy Diazgranados, Andrea F. DiMartini, Daniel E. Falk, Anne C. Fernandez, Margarita N. German, Patrick S. Kamath, Kelley M. Kidwell, Lorenzo Leggio, Raye Litten, Alexandre Louvet, Michael R. Lucey, Mary E. McCaul, Arun J. Sanyal, Ashwani K. Singal, Norman L. Sussman, Norah A. Terrault, Mark R. Thursz, Elizabeth C. Verna, Svetlana Radaeva, Laura E. Nagy, Mack C. Mitchell
1w ago
Nature Reviews Gastroenterology & Hepatology, Published online: 07 June 2024; doi:10.1038/s41575-024-00936-x Alcohol-associated liver disease is the main cause of liver-related morbidity and mortality globally. This Consensus Statement makes recommendations for the design, best practice and conduct of clinical trials to evaluate the effects of alcohol use in alcohol-associated liver disease and alcohol use disorder ..read more
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Shaping new paths in clinical trial design to address alcohol use disorders and alcohol-associated liver disease
Nature Reviews Gastroenterology & Hepatology
by Juliana Serrazina, Helena Cortez-Pinto
1w ago
Nature Reviews Gastroenterology & Hepatology, Published online: 07 June 2024; doi:10.1038/s41575-024-00948-7 An expert panel has proposed 28 recommendations for the design and conduct of clinical trials for alcohol use disorders and alcohol-associated liver disease. This field has a scarcity of clinical trials, despite alcohol abuse and alcohol-related liver disease being one of the greatest causes of morbidity and mortality worldwide ..read more
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Envisioning how to advance the MASH field
Nature Reviews Gastroenterology & Hepatology
by Alina M. Allen, Zobair M. Younossi, Anna Mae Diehl, Michael R. Charlton, Jeffrey V. Lazarus
2w ago
Nature Reviews Gastroenterology & Hepatology, Published online: 04 June 2024; doi:10.1038/s41575-024-00938-9 This Perspective discusses the nomenclature change from nonalcoholic fatty liver disease to metabolic dysfunction-associated steatotic liver disease (MASLD) and proposes steps necessary to improve care and end the public health threat posed by MASLD and metabolic dysfunction-associated steatohepatitis ..read more
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A global consensus on the definitions, diagnosis and management of fibrostenosing small bowel Crohn’s disease in clinical practice
Nature Reviews Gastroenterology & Hepatology
by Dominik Bettenworth, Mark E. Baker, Joel G. Fletcher, Vipul Jairath, Cathy Lu, Willem Bemelman, Geert d’Haens, Andre d’Hoore, Axel Dignass, Iris Dotan, Roger Feakins, Phillip Fleshner, Christina Ha, Gaylyn Henderson, Ruishen Lyu, Julian Panes, Gerhard Rogler, Ren Mao, Jordi Rimola, William J. Sandborn, Siew C. Ng, Britta Siegmund, Mark Silverberg, Stuart A. Taylor, Bram Verstockt, Ilyssa O. Gordon, David H. Bruining, Brian G. Feagan, Florian Rieder
2w ago
Nature Reviews Gastroenterology & Hepatology, Published online: 03 June 2024; doi:10.1038/s41575-024-00935-y In this Consensus Statement, a global multidisciplinary panel of experts provides recommendations for the definitions, diagnosis and management of patients with fibrostenosing small bowel Crohn’s disease ..read more
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Endogenous ethanol production in health and disease
Nature Reviews Gastroenterology & Hepatology
by Abraham S. Meijnikman, Max Nieuwdorp, Bernd Schnabl
2w ago
Nature Reviews Gastroenterology & Hepatology, Published online: 03 June 2024; doi:10.1038/s41575-024-00937-w Ethanol is produced in the gut by several different species of fermentative bacteria. This Review discusses the sources and consequences of endogenously produced ethanol, explores its relationship with liver diseases such as metabolic dysfunction-associated steatotic liver disease and covers approaches to target excessive ethanol production in the gut ..read more
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Hybrid APASL meeting 2024
Nature Reviews Gastroenterology & Hepatology
by Eleni Kotsiliti
2w ago
Nature Reviews Gastroenterology & Hepatology, Published online: 03 June 2024; doi:10.1038/s41575-024-00949-6 Hybrid APASL meeting 2024 ..read more
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