Nature Reviews Gastroenterology & Hepatology, Published online: 22 July 2024; doi:10.1038/s41575-024-00950-z Many aspects of the biology and pathogenesis of hepatitis E virus (HEV) infection remain underexplored. In this Review, Steinmann and colleagues summarize the role of the innate and adaptive immune systems in HEV infection ..read more

Nature Reviews Gastroenterology & Hepatology, Published online: 22 July 2024; doi:10.1038/s41575-024-00969-2 Shifting targets for eosinophilic oesophagitis ..read more

Nature Reviews Gastroenterology & Hepatology, Published online: 17 July 2024; doi:10.1038/s41575-024-00955-8 Metabolic dysfunction-associated steatohepatitis (MASH), a primary cause of chronic liver disease (CLD), often leads to advanced CLD stages such as cirrhosis. This Roadmap summarizes the current landscape and challenges of MASH-related compensated cirrhosis clinical trials and explores a way forward for future studies ..read more

Nature Reviews Gastroenterology & Hepatology, Published online: 15 July 2024; doi:10.1038/s41575-024-00958-5 Globally, one in six people have a disability, and individuals with disabilities often experience a narrow margin of health, less financial security and health disparities. We call for action to improve access to health care for people with disabilities and show how this plan might be achieved ..read more

Nature Reviews Gastroenterology & Hepatology, Published online: 11 July 2024; doi:10.1038/s41575-024-00966-5 Neoadjuvant immunotherapy for mismatch repair-deficient colon cancer: a phase II study ..read more

Nature Reviews Gastroenterology & Hepatology, Published online: 11 July 2024; doi:10.1038/s41575-024-00965-6 Fgfbp1+ cells: upper crypt intestinal epithelial regeneration ..read more

Nature Reviews Gastroenterology & Hepatology, Published online: 02 July 2024; doi:10.1038/s41575-024-00960-x ETS2 regulates human inflammatory macrophages in IBD ..read more

Nature Reviews Gastroenterology & Hepatology, Published online: 17 June 2024; doi:10.1038/s41575-024-00954-9 Digestive Disease Week 2024 ..read more

Nature Reviews Gastroenterology & Hepatology, Published online: 14 June 2024; doi:10.1038/s41575-024-00951-y The advent of next-generation RAS inhibitors brings renewed optimism to the care of patients with pancreatic cancer after decades of failure for novel therapeutics. A recent study highlights the potent antitumour activity of the multi-selective RAS(ON) inhibitor RMC-7977 across a spectrum of preclinical pancreatic cancer models ..read more

Nature Reviews Gastroenterology & Hepatology, Published online: 14 June 2024; doi:10.1038/s41575-024-00952-x This Comment reviews the evolution from early electrophysiological studies to advanced diagnostic tools, highlighting the challenges and innovations shaping the future of gastrointestinal diagnostics ..read more