Creating an evidence-based economic model for prefilled parenteral medication delivery in the hospital setting
European Journal of Hospital Pharmacy
by Eijsink, J. F. H., Weiss, M., Taneja, A., Edwards, T., Girgis, H., Lahue, B. J., Cribbs, K. A., Postma, M.
1M ago
Objectives Prefilled syringes (PFS) may offer clinical and economic advantages over conventional parenteral medication delivery methods (vials and ampoules). The benefits of converting from vials and ampoules to PFS have been explained in previous drug-specific economic models; however, these models have limited generalisability to different drugs, healthcare settings and other countries. Our study aims to (1) present a comprehensive economic model to assess the impact of switching from vials to PFS delivery; and (2) illustrate through two case studies the model’s utility by highlighting impor ..read more
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Physicochemical stability of ready-to-administer mitomycin C solutions for intravesical instillation
European Journal of Hospital Pharmacy
by Almasi, J., Thiesen, J., Kraemer, I.
1M ago
Objective The aim of the study was to investigate the physicochemical stability of mitomycin-containing medicinal products for bladder instillation, formulated with urea as excipient (mito-medac®, Mitomycin medac). For comparison, the stability of reconstituted Urocin® and Mitem® bladder instillation was studied. Methods Mitomycin-containing medicinal products were either reconstituted with the prepackaged 0.9% NaCl solution, nominal volume 20 mL (mito-medac®, Mitem®, Urocin®) or with 20 mL water for injection (Mitomycin medac, Mitem®, Urocin®) to a nominal concentration of 1 mg/mL and stored ..read more
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Risk of exposure of patients family members to lenalidomide at home
European Journal of Hospital Pharmacy
by Takahashi, Y., Nagamine, A., Kaneta, A., Yashima, H., Obayashi, K., Araki, T., Yamamoto, K.
1M ago
Objectives Lenalidomide, a hazardous drug, has strict distribution controls. However, the risk of contamination with lenalidomide when patients take the drug has not been studied and the risk of drug exposure to people in the patient’s living environment is unknown. Thus, we investigated the amount of lenalidomide that could be dispersed during the period between removal of the capsule and returning the used blister packages, and we considered the conditions under which lenalidomide could be dispersed and countermeasures. Methods The amount of lenalidomide contamination was measured on the out ..read more
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Evaluation of drug interaction between cyclosporine and lercanidipine: a descriptive study
European Journal of Hospital Pharmacy
by Tecen-Yucel, K., Bayraktar-Ekincioglu, A., Yıldırım, T., Demirkan, K., Erdem, Y.
1M ago
Objectives Cyclosporine is an immunosuppressive drug with a high potential for drug interactions that is frequently used in renal transplant patients. The purpose of this study was to assess the change in cyclosporine concentration in patients taking cyclosporine and lercanidipine concurrently. Methods The potential drug interactions in renal transplant patients who received lercanidipine and cyclosporine concurrently in a university hospital between January 2008 and January 2018 were evaluated retrospectively. Patients had renal transplantation from deceased donors or living related donors. T ..read more
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Performance and risks of ChatGPT used in drug information: an exploratory real-world analysis
European Journal of Hospital Pharmacy
by Morath, B., Chiriac, U., Jaszkowski, E., Deiss, C., Nürnberg, H., Hörth, K., Hoppe-Tichy, T., Green, K.
1M ago
Objectives To investigate the performance and risk associated with the usage of Chat Generative Pre-trained Transformer (ChatGPT) to answer drug-related questions. Methods A sample of 50 drug-related questions were consecutively collected and entered in the artificial intelligence software application ChatGPT. Answers were documented and rated in a standardised consensus process by six senior hospital pharmacists in the domains content (correct, incomplete, false), patient management (possible, insufficient, not possible) and risk (no risk, low risk, high risk). As reference, answers were rese ..read more
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A retrospective hospital benefit and cost analysis of the management of human tissues for orthopaedic allografts
European Journal of Hospital Pharmacy
by Ossato, A., Mezzadrelli, V., Montagner, G., Trojan, D., Giovagnoni, G., Giannini, M., Trabucchi, C., Angelini, C., Realdon, F., Cipriano, L., Realdon, N., Zuppini, T., Tessari, R.
1M ago
Objectives The transplantation of human tissues is a greatly expanding field of medicine with unquestionable benefits that raise questions about safety, quality and ethics. Since 1 October 2019, the Fondazione Banca dei Tessuti del Veneto (FBTV) stopped sending thawed and ready to be transplanted cadaveric human tissues to hospitals. A retrospective analysis of the period 2016–2019 found a significant number of unused tissues. For this reason, the hospital pharmacy has developed a new centralised service characterised by thawing and washing human tissues for orthopaedic allografts. This study ..read more
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Real-world effectiveness and factors associated with increased mortality in non-critically ill patients with COVID-19 pneumonia receiving remdesivir
European Journal of Hospital Pharmacy
by Quesada Munoz, L., Fernandez-Fradejas, J., Martinez-Barros, H., Sanchez Cuervo, M., Martin Rufo, M., Pintor Recuenco, M. d. R., Quereda Rodriguez-Navarro, C., Alvarez-Diaz, A. M., Saez de la Fuente, J.
1M ago
Objectives Evidence on the effectiveness of remdesivir when used in real-life clinical practice is controversial. This study aims to analyse its effectiveness and the factors associated with increased mortality in non-critically ill patients with COVID-19 pneumonia who require supplemental low-flow oxygen and received remdesivir. Methods A retrospective cohort study was conducted at Ramón y Cajal University Hospital (Madrid, Spain) which included all patients treated with remdesivir in our institution during the second pandemic breakout in Spain, from August to November 2020. Treatment with re ..read more
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Questions around a case of in utero thrombosis in a premature child, concerning the management of anticoagulant treatments
European Journal of Hospital Pharmacy
by Gerard, D., Callies, A., Simon, L., Ternisien, C., Prot-Labarthe, S.
1M ago
We report the case of a preterm infant presenting a thrombosis, discovered on ultrasound at 22 weeks of gestational age and confirmed at birth following additional examinations. We describe the anticoagulant treatment of this patient by intravenous enoxaparin, tinzaparin and rivaroxaban, from questioning to practice ..read more
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Evaluation of drug cost savings related to clinical trials from the perspective of a university hospital
European Journal of Hospital Pharmacy
by Perrier, Q., Minoves, M., Cerana, S., Reymond, F., Ducki, C., Decaens, T., Lehmann, A., Bedouch, P.
1M ago
Objectives Clinical trials are an opportunity for patients to access innovative therapy, but patient inclusion in clinical trials can also result in cost savings for hospitals. Our objective was to evaluate the economic impact of clinical trials drug cost savings in a French academic institution from the perspectives of both the French Health Insurance (FHI) and hospitals. Methods A retrospective, observational, cost saving analysis was performed on all the clinical trials initiated in our university hospital between 2015 and 2020. Only trials involving an investigational medicinal product wer ..read more
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Adverse reactions to antimicrobials in pediatric patients admitted to a tertiary hospital: a cohort study
European Journal of Hospital Pharmacy
by Leitzke, L. R. F., Lenhart, G., Rocha, A. L., Zamberlan, S., Gnatta, D., da Costa Lima, E., Heineck, I.
1M ago
Background Antimicrobials are widely used in hospitals and are often associated with adverse drug reactions (ADRs). The objective of this study was to determine the incidence of ADRs caused by antimicrobials and classify them according to the type of reaction, the class of antimicrobials used, causality, severity and avoidability. Methods A prospective cohort study was carried out with paediatric patients for 6 months. Causality was verified using the Naranjo and Liverpool algorithms, the severity was verified with the adapted scale of Hartwig and the avoidability was verified with the Liverpo ..read more
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