Attracting B cells
BartsMS Blog
by MouseDoctor
6h ago
“B cells are considered main triggers of the disease” I though the message is filtering through but then I saw the authors and it is one of the claiments in developing anti-CD20 for MS. Here they look at identical twins and ask is there a difference in the B cells between the twins. The frequencies of CXCR3+ memory B cells were reduced in the blood of genetically identical twins with MS compared to their unaffected twin siblings. CXCR3 is a receptor for a chemokine which attracts cells to move towards the chemokine CXCL10 which is found in the cerebrospinal fluid in MS. Is this a key reas ..read more
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It’s a Mystery…It’s a Mystery…Waiting for a Clue.. Here it is….Raw and Saw
BartsMS Blog
by MouseDoctor
1d ago
Hopefully this is not a horror story…. ProfG has been thinking again as an alternative to PIRA which I said previously was a flawed measure descriptor as some of it is due to the aftermath of active lesions. ProfG likes his smoldering and SAW is smoldering associated worsening as opposed to relapse associated worsening. Here is the work of Niraj Mistry. Neuromyelitis is RAW without the SAW MS is RAW & SAW Reconciling lesions, relapses and smouldering associated worsening: A unifying model for multiple sclerosis pathogenesis Niraj Mistry, Hobart J, Rog D, Muhlert N, Mathews  ..read more
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EBV making T cells feel old
BartsMS Blog
by MouseDoctor
2d ago
Whilst many people are still sceptical about the importance of EBV in the development of MS, even more people are sceptical about whether EBV is in the brain. It is is sort of important to be sure because this determines when and how you should try to deal with EBV…Get it wrong and your trial probably fails, So the major drum beaters for EBV in the brain is back again to tell us more about the EBV infected B cells. PD-1L was expressed on B cells and PD-1 on T cells put the two together and the T cells get a brake on their activity and maybe the virally infected cells lives for abit longer Ser ..read more
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EBV
BartsMS Blog
by MouseDoctor
3d ago
Nice study but I would still say “the precise mechanisms for such influences are still unclear” Huang J, Tengvall K, Bomfim Lima I, Hedström AK, Butt J, Brenner N, Gyllenberg A, Stridh P, Khademi M, Ernberg I, Al Nimer F, Manouchehrinia A, Hillert J, Alfredsson L, Andersen O, Sundström P, Waterboer T, Olsson T, Kockum I. Genetics of immune response to Epstein-Barr virus: prospects for multiple sclerosis pathogenesis. Brain. 2024:awae110. doi: 10.1093/brain/awae110. Epub ahead of print.  Epstein-Barr virus (EBV) infection has been advocated as a prerequisite for developing multiple scleros ..read more
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Cladribine in the real world
BartsMS Blog
by MouseDoctor
4d ago
Manni A, Oggiano F, Palazzo C, Panetta V, Gargano CD, Mangialardi V, Guerra T, Iaffaldano A, Caputo F, Iaffaldano P, Ruggieri M, Trojano M, Paolicelli D. Clinical and biological predictors of Cladribine effectiveness in Multiple Sclerosis: A real-world, single centre study considering a two-year interval from year-2 dosing. J Neurol Sci. 2024; 462:123070. Objectives: Cladribine tablets (CLAD) for adult patients with highly active relapsing multiple sclerosis (RMS) have been available in Italy since 2018. We aimed to assess predictors of no-evidence-of-disease-activity-3 (NEDA-3) status af ..read more
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From Pipelines to Ideas about progression?
BartsMS Blog
by MouseDoctor
5d ago
I am doing a talk this week on the the Future of MS and research Ideas….So a few days ago I was looking what is in store for MS in the near future and sorry to say it was more of the same coming your way. Why do I think that? Well in the omics era we can look at trial-omics to see what is in phase III development these may take up to 5 years to land on your doorstep. There is stuff in phase II but a few years for their studies to report and then the three-five years for the phase III trial or trials to recruit and report. Where do I get my trial-omics from? Well places like http://www.clinical ..read more
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T25FW is more sensitive than the EDSS for early progression
BartsMS Blog
by Neuro Doc Gnanapavan
1w ago
It’s not surprising that the EDSS scoring system that relies on different functional systems (eyes, balance, sensation etc) to give a total score is not that sensitive at the lower end of the scale in detecting early progression. Progression intrinsically is most noticeable with deterioration in walking because your legs are the furthest away from your brain (increased likelihood of being affected by lesions) and requires a certain threshold of neurones to support its smooth functioning. Measures that focus on walking can pick this up and show changes earlier than the EDSS. Though not sophisti ..read more
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The Great and the Good not on an Ozanimod Paper will that convince NICE to approve it…Will they get the option to do this?
BartsMS Blog
by MouseDoctor
1w ago
Many science papers about pharmaceutical drugs could be considered as advertisements for the drugs they are reporting. They invariably are written by medical writers to conform to the rules of the Land such as the Association of British Pharmaceutical Industry (www.abpi.org.uk) to ensure balance. They then stick some mouth pieces on the papers, which are typically neurological opinion leaders and may have been on the advisory boards during the drug development. The Jobbing neurologists reads the papers, trusts the authors, after all they are on so many clinical trial papers, and this gives the ..read more
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Developmental origin of oligodendrocytes determines their function in the adult brain
BartsMS Blog
by MouseDoctor
1w ago
If interested please read Foerster S, Floriddia EM, van Bruggen D, Kukanja P, Hervé B, Cheng S, Kim E, Phillips BU, Heath CJ, Tripathi RB, Call C, Bartels T, Ridley K, Neumann B, López-Cruz L, Crawford AH, Lynch CJ, Serrano M, Saksida L, Rowitch DH, Möbius W, Nave KA, Rasband MN, Bergles DE, Kessaris N, Richardson WD, Bussey TJ, Zhao C, Castelo-Branco G, Franklin RJM. Developmental origin of oligodendrocytes determines their function in the adult brain. Nat Neurosci. 2024 Jun 7. doi: 10.1038/s41593-024-01666-8. In the mouse embryonic forebrain, developmentally distinct oligodendrocyte progenit ..read more
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Rachel Horne’s Prize for Women’s Research in MS
BartsMS Blog
by MouseDoctor
1w ago
Here’s a piece I wrote which appeared first in the journal MS and Related Disorders last month. Horne R. Why I created the Rachel Horne Prize for Women’s Research in Multiple Sclerosis. Mult Scler Relat Disord. 2024;87:105693. doi: 10.1016/j.msard.2024.105693 Why I created the RH Prize for Women’s Research in MS By Rachel Horne I never envisaged I would set up a medical award, especially one with a disease in the title. But, then again, I never thought I would be diagnosed at the age of 43 with multiple sclerosis (MS). After a few difficult years, I decided to learn as muc ..read more
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