NANOG controls testicular germ cell tumour stemness through regulation of MIR9-2
BMC » Stem Cell Research & Therapy
by Ryan P Cardenas, Ahmad Zyoud, Alan McIntyre, Ramiro Alberio, Nigel P Mongan and Cinzia Allegrucci
1d ago
Testicular germ cell tumours (TGCTs) represent a clinical challenge; they are most prevalent in young individuals and are triggered by molecular mechanisms that are not fully understood. The origin of TGCTs ca ..read more
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MSCs promote the efferocytosis of large peritoneal macrophages to eliminate ferroptotic monocytes/macrophages in the injured endometria
BMC » Stem Cell Research & Therapy
by Jiali Wang, Jingman Li, Lijie Yin, Xiuzhu Wang, Yue Dong, Guangfeng Zhao, Sunan Shen and Yayi Hou
1d ago
Endometria are one of the important components of the uterus, which is located in the peritoneal cavity. Endometrial injury usually leads to intrauterine adhesions (IUA), accompanied by inflammation and cell d ..read more
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Correction: Administration of adipose-derived stem cells extracellular vesicles in a murine model of spinal muscular atrophy: effects of a new potential therapeutic strategy
BMC » Stem Cell Research & Therapy
by Federica Virla, Ermanna Turano, Ilaria Scambi, Lorenzo Schiaffino, Marina Boido and Raffaella Mariotti
1d ago
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Safety and efficacy of umbilical cord tissue-derived mesenchymal stem cells in the treatment of patients with aging frailty: a phase I/II randomized, double-blind, placebo-controlled study
BMC » Stem Cell Research & Therapy
by Yingqian Zhu, Ce Huang, Liang Zheng, Qingqing Li, Jianli Ge, ShaSha Geng, Miaomiao Zhai, Xin Chen, Huixiao Yuan, Yang Li, Wenwen Jia, Keping Sun, Yan Li, Tong Ye, Zhengmei Zhao, Hailiang Liu…
4d ago
Mesenchymal stem cells (MSCs) hold a great promise for cell-based therapy in the field of regenerative medicine. In this study, we aimed to evaluate the safety and efficacy of intravenous infusion of human umb ..read more
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RhBMP-2 induces terminal differentiation of human bone marrow mesenchymal stromal cells only by synergizing with other signals
BMC » Stem Cell Research & Therapy
by Neda Kathami, Carolina Moreno-Vicente, Pablo Martín, Jhonatan A. Vergara-Arce, Raquel Ruiz-Hernández, Daniela Gerovska, Ana M. Aransay, Marcos J. Araúzo-Bravo, Sandra Camarero-Espinosa and Ander Abarrategi
4d ago
Recombinant human bone morphogenetic protein 2 (rhBMP-2) and human bone marrow mesenchymal stromal cells (hBM-MSCs) have been thoroughly studied for research and translational bone regeneration purposes. rhBMP ..read more
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Thrombopoietin mimetic stimulates bone marrow vascular and stromal niches to mitigate acute radiation syndrome
BMC » Stem Cell Research & Therapy
by Justin Vercellino, Beata Małachowska, Shilpa Kulkarni, Brett I. Bell, Shahin Shajahan, Kosaku Shinoda, Gary Eichenbaum, Amit K. Verma, Sanchita P. Ghosh, Weng-Lang Yang, Paul S. Frenette and Chandan Guha
4d ago
Acute radiation syndrome (ARS) manifests after exposure to high doses of radiation in the instances of radiologic accidents or incidents. Facilitating regeneration of the bone marrow (BM), namely the hematopoi ..read more
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Mesenchymal stromal/stem cells promote intestinal epithelium regeneration after chemotherapy-induced damage
BMC » Stem Cell Research & Therapy
by B. Yetkin-Arik, S. A. Jansen, S. Varderidou-Minasian, B. Westendorp, K.-P. Skarp, M. Altelaar, C. A. Lindemans and M. J. Lorenowicz
4d ago
Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative treatment for leukemia and a range of non-malignant disorders. The success of the therapy is hampered by occurrence of acute graft-versus ..read more
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Synergistic effect of human uterine cervical mesenchymal stem cell secretome and paclitaxel on triple negative breast cancer
BMC » Stem Cell Research & Therapy
by Noemi Eiro, Maria Fraile, Sara Escudero-Cernuda, Juan Sendon-Lago, Luis O. Gonzalez, Maria Luisa Fernandez-Sánchez and Francisco J. Vizoso
4d ago
Triple-negative breast cancer (TNBC) is the most lethal subtype of breast cancer and, despite its adverse effects, chemotherapy is the standard systemic treatment option for TNBC. Since, it is of utmost import ..read more
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Subcutaneous injection of adipose stromal cell-secretome improves renal function and reduces inflammation in established acute kidney injury
BMC » Stem Cell Research & Therapy
by Md Mahbub Ullah, Jason A. Collett, Jacob C. Monroe, Dmitry Traktuev, Michael Coleman, Keith L. March and David P. Basile
1w ago
Adipose stromal cells (ASC) are a form of mesenchymal stromal cells that elicit effects primarily via secreted factors, which may have advantages for the treatment of injury or disease. Several previous studie ..read more
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Simple modeling of familial Alzheimer’s disease using human pluripotent stem cell-derived cerebral organoid technology
BMC » Stem Cell Research & Therapy
by Mu Seog Choe, Han Cheol Yeo, Joong Sun Kim, Jean Lee, Hae Jun Lee, Hyung-Ryong Kim, Kyung Min Baek, Na-Yeon Jung, Murim Choi and Min Young Lee
1w ago
Cerebral organoids (COs) are the most advanced in vitro models that resemble the human brain. The use of COs as a model for Alzheimer’s disease (AD), as well as other brain diseases, has recently gained attent ..read more
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