The establishment and regulation of human germ cell lineage
BMC » Stem Cell Research & Therapy
by Honglin Yu, Ziqi Wang, Jiayue Ma, Ruoming Wang, Shuo Yao, Zhaoyu Gu, Kexin Lin, Jinlan Li, Robert S. Young, Ya Yu, You Yu, Min Jin and Di Chen
3d ago
The specification of primordial germ cells (PGCs) during early embryogenesis initiates the development of the germ cell lineage that ensures the perpetuation of genetic and epigenetic information from parents ..read more
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Enhancing myelinogenesis through LIN28A rescues impaired cognition in PWMI mice
BMC » Stem Cell Research & Therapy
by Xuan Wu, Zhechun Hu, Huimin Yue, Chao Wang, Jie Li, Yinxiang Yang, Zuo Luan, Liang Wang, Ying Shen and Yan Gu
3d ago
In premature newborn infants, preterm white matter injury (PWMI) causes motor and cognitive disabilities. Accumulating evidence suggests that PWMI may result from defected differentiation of oligodendrocyte pr ..read more
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Exploring the impact of gut microbiota-mediated regulation of exosomal miRNAs from bone marrow mesenchymal stem cells on the regulation of bone metabolism
BMC » Stem Cell Research & Therapy
by Bin He, Xianglin Shen, Feng Li, Rudan Zhou, Haiyan Xue, Xianqiu Fan, Zhihua Wang, Xinpeng Guo, Yu Fan, Guanghu Luo, Xiujun Zhang and Hongyu Zheng
3d ago
Osteoporosis, which is a prevalent metabolic bone disease, is closely associated with imbalances in the gut microbiota ..read more
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Extracellular vesicles derived from mesenchymal stem cells alleviate renal fibrosis via the miR-99b-5p/mTOR/autophagy axis in diabetic kidney disease
BMC » Stem Cell Research & Therapy
by Rongrong Li, Hongyan Tao, Kai Pan, Rui Li, Zhikun Guo, Xiaoniao Chen and Zongjin Li
3d ago
Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease (ESRD) globally, presenting a significant therapeutic challenge. Extracellular vesicles (EVs) from mesenchymal stem cells (MSCs) ha ..read more
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RNA-binding protein SAMD4A targets FGF2 to regulate cardiomyocyte lineage specification from human embryonic stem cells
BMC » Stem Cell Research & Therapy
by Na Yi, Han-rui Wang, Yu-ping Zhu, Tao Xiao, Qin Lin, Huan Liu, Yi-lei Meng, Yi-zhuo Sun, Fang Lin, Sang-yu Hu, Hua-ming Cao, Jun-fang Zhang, Lu-ying Peng and Li Li
3d ago
RNA-binding proteins (RBPs) are essential in cardiac development. However, a large of them have not been characterized during the process ..read more
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Reviving hope: unlocking pancreatic islet immortality by optimizing a trehalose-based cryopreservation media and cell-penetrating peptide
BMC » Stem Cell Research & Therapy
by Zakieh Samsonchi, Roshanak Amirian, Lobat Tayebi, Hossein Derakhshankhah, Zhila Izadi and Ensiyeh Hajizadeh-Saffar
1w ago
Diabetes mellitus remains a pervasive global health concern, urging a deeper exploration of islet transplantation as a potential enduring solution. The efficacy of this therapeutic approach pivots on the preci ..read more
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Circ-AARS plays an important role during the odontogenic differentiation of dental pulp stem cells by modulating miR-24-3p/KLF6 expression
BMC » Stem Cell Research & Therapy
by Meizhi Sui, Jiaxuan Lyu, Jiaxin Zhou, Qian Liao, Zexu Xiao, Mingming Jin and Jiang Tao
1w ago
Circular RNAs (circRNAs) play a crucial role in stem cell-based tooth regeneration. However, the functions and underlying mechanisms of circRNAs in tooth regeneration from human dental pulp stem cells (DPSCs ..read more
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Umbilical mesenchymal stem cells mitigate T-cell compartments shift and Th17/Treg imbalance in acute ischemic stroke via mitochondrial transfer
BMC » Stem Cell Research & Therapy
by Shuna Chen, Chao Han, Zihan Shi, Xin Guan, Liyuan Cheng, Liang Wang, Wei Zou and Jing Liu
1w ago
Acute ischemic stroke (AIS) initiates secondary injuries that worsen neurological damage and hinder recovery. While peripheral immune responses play a key role in stroke outcomes, clinical results from immunot ..read more
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Mesenchymal cell-derived exosomes and miR-29a-3p mitigate renal fibrosis and vascular rarefaction after renal ischemia reperfusion injury
BMC » Stem Cell Research & Therapy
by Jing Huang, Lang Shi, Yifei Yang, Fan Zhao, Rengui Chen, Wenliang Liao, Jiefu Zhu, Dingping Yang, Xiongfei Wu and Shangting Han
1w ago
Renal fibrosis and vascular rarefaction are significant complications of ischemia/reperfusion (I/R) injury. Human umbilical cord mesenchymal cell-derived exosomes (hucMSC-exos) have shown potential in mitigati ..read more
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Enhanced mitochondrial function and delivery from adipose-derived stem cell spheres via the EZH2-H3K27me3-PPARγ pathway for advanced therapy
BMC » Stem Cell Research & Therapy
by Ming-Min Chang, Dinh Toi Chu, Sheng-Che Lin, Jung-Shun Lee, Thuy Duong Vu, Hue Thi Vu, Thamil Selvee Ramasamy, Shau-Ping Lin and Chia-Ching Wu
1w ago
Microenvironmental alterations induce significant genetic and epigenetic changes in stem cells. Mitochondria, essential for regenerative capabilities, provide the necessary energy for stem cell function. Howev ..read more
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