Cell-specific extracellular vesicle-encapsulated exogenous GABA controls seizures in epilepsy
BMC » Stem Cell Research & Therapy
by Abhijna Ballal R, Shivakumar Reddy K, Divya Chandran, Sumukha Hegde, Raghavendra Upadhya, Praveen Kumar SE, Smita Shenoy, Vasudha Devi and Dinesh Upadhya
9h ago
Epilepsy affects ∼60 million people worldwide. Most antiseizure medications in the market act on voltage-gated sodium or calcium channels, indirectly modulating neurotransmitter GABA or glutamate levels or mul ..read more
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Transcriptomic profiling across human serotonin neuron differentiation via the FEV reporter system
BMC » Stem Cell Research & Therapy
by Yingqi Li, Jinjin Duan, You Li, Meihui Zhang, Jiaan Wu, Guanhao Wang, Shuanqing Li, Zhangsen Hu, Yi Qu, Yunhe Li, Xiran Hu, Fei Guo, Lining Cao and Jianfeng Lu
9h ago
The detailed transcriptomic profiles during human serotonin neuron (SN) differentiation remain elusive. The establishment of a reporter system based on SN terminal selector holds promise to produce highly-puri ..read more
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Treatment of COVID-19-associated ARDS with umbilical cord-derived mesenchymal stromal cells in the STROMA-CoV-2 multicenter randomized double-blind trial: long-term safety, respiratory function, and quality of life
BMC » Stem Cell Research & Therapy
by Alexandre Sitbon, Caroline Hauw-Berlemont, Miryam Mebarki, Nicholas Heming, Julien Mayaux, Jean-Luc Diehl, Alexandre Demoule, Djillali Annane, Clémence Marois, Sophie Demeret, Emmanuel Weiss, Guillaume Voiriot, Muriel Fartoukh, Jean‐Michel Constantin, Bruno Mégarbane, Gaëtan Plantefève…
9h ago
The STROMA-CoV-2 study was a French phase 2b, multicenter, double-blind, randomized, placebo-controlled clinical trial that did not identify a significant efficacy of umbilical cord-derived mesenchymal stromal ..read more
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Monoallelic KRAS (G13C) mutation triggers dysregulated expansion in induced pluripotent stem cell-derived hematopoietic progenitor cells
BMC » Stem Cell Research & Therapy
by Huan-Ting Lin, Masatoshi Takagi, Kenji Kubara, Kazuto Yamazaki, Fumiko Michikawa, Takashi Okumura, Takuya Naruto, Tomohiro Morio, Koji Miyazaki, Hideki Taniguchi and Makoto Otsu
3d ago
Although oncogenic RAS mutants are thought to exert mutagenic effects upon blood cells, it remains uncertain how a single oncogenic RAS impacts non-transformed multipotent hematopoietic stem or progenitor cells ..read more
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An integrated toolkit for human microglia functional genomics
BMC » Stem Cell Research & Therapy
by Imdadul Haq, Jason C. Ngo, Nainika Roy, Richard L. Pan, Nadiya Nawsheen, Rebecca Chiu, Ya Zhang, Masashi Fujita, Rajesh K. Soni, Xuebing Wu, David A. Bennett, Vilas Menon, Marta Olah and Falak Sher
1w ago
Microglia, the brain’s resident immune cells, play vital roles in brain development, and disorders like Alzheimer’s disease (AD). Human iPSC-derived microglia (iMG) provide a promising model to study these pro ..read more
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Allogeneic bone marrow mesenchymal stem cell-derived exosomes alleviate human hypoxic AKI-on-a-Chip within a tight treatment window
BMC » Stem Cell Research & Therapy
by Sefa Burak Çam, Eda Çiftci, Nazlıhan Gürbüz, Bülent Altun and Petek Korkusuz
1w ago
Acute hypoxic proximal tubule (PT) injury and subsequent maladaptive repair present high mortality and increased risk of acute kidney injury (AKI) - chronic kidney disease (CKD) transition. Human bone marrow m ..read more
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Small-molecule α-lipoic acid targets ELK1 to balance human neutrophil and erythrocyte differentiation
BMC » Stem Cell Research & Therapy
by Yimeng Zhang, Ya Zhou, Xiaohong Li, Xu Pan, Ju Bai, Yijin Chen, Zhenyang Lai, Qiang Chen, Feng Ma and Yong Dong
1w ago
Erythroid and myeloid differentiation disorders are commonly occurred in leukemia. Given that the relationship between erythroid and myeloid lineages is still unclear. To find the co-regulators in erythroid an ..read more
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Utilizing bioprinting to engineer spatially organized tissues from the bottom-up
BMC » Stem Cell Research & Therapy
by Yichen Zhan, Wenbin Jiang, Zhirong Liu, Zhenxing Wang, Ke Guo and Jiaming Sun
1w ago
In response to the growing demand for organ substitutes, tissue engineering has evolved significantly. However, it is still challenging to create functional tissues and organs. Tissue engineering from the ‘bot ..read more
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Oral ulcer treatment using human tonsil-derived mesenchymal stem cells encapsulated in trimethyl chitosan hydrogel: an animal model study
BMC » Stem Cell Research & Therapy
by Hyun Seok Ryu, Celine Abueva, Andrew Padalhin, So Young Park, Seung Hyeon Yoo, Hwee Hyon Seo, Phil-Sang Chung and Seung Hoon Woo
1w ago
Oral ulcers are a common side effect of chemotherapy and affect patients’ quality of life. While stem cell transplantation is a potential treatment for oral ulcers, its efficacy is limited as the stem cells te ..read more
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Mesenchymal stromal cell chondrogenesis under ALK1/2/3-specific BMP inhibition: a revision of the prohypertrophic signalling network concept
BMC » Stem Cell Research & Therapy
by Solvig Diederichs, Simon I. Dreher, Sarah Anna Nüesch, Sven Schmidt, Christian Merle and Wiltrud Richter
2w ago
In vitro chondrogenesis of mesenchymal stromal cells (MSCs) driven by the essential chondro-inducer transforming growth factor (TGF)-β is instable and yields undesired hypertrophic cartilage predisposed to bon ..read more
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