Stepwise combined cell transplantation using mesenchymal stem cells and induced pluripotent stem cell-derived motor neuron progenitor cells in spinal cord injury
BMC » Stem Cell Research & Therapy
by Jang-Woon Kim, Juryun Kim, Hyunkyung Mo, Heeju Han, Yeri Alice Rim and Ji Hyeon Ju
2d ago
Spinal cord injury (SCI) is an intractable neurological disease in which functions cannot be permanently restored due to nerve damage. Stem cell therapy is a promising strategy for neuroregeneration after SCI ..read more
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DPSCs regulate epithelial-T cell interactions in oral submucous fibrosis
BMC » Stem Cell Research & Therapy
by S. Y. Wang, S. J. Zhang, H. F. Meng, H. Q. Xu, Z. X. Guo, J. F. Yan, J. L. Gao, L. N. Niu, S. L. Wang and K. Jiao
2d ago
Oral submucous fibrosis (OSF) is a precancerous lesion characterized by fibrous tissue deposition, the incidence of which correlates positively with the frequency of betel nut chewing. Prolonged betel nut chew ..read more
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Mesenchymal stem cells promote ovarian reconstruction in mice
BMC » Stem Cell Research & Therapy
by Jiazhao Li, Haonan Fan, Wei Liu, Jing Zhang, Yue Xiao, Yue Peng, Weijie Yang, Wenwen Liu, Yuanlin He, Lianju Qin, Xiang Ma and Jing Li
2d ago
Studies have shown that chemotherapy and radiotherapy can cause premature ovarian failure and loss of fertility in female cancer patients. Ovarian cortex cryopreservation is a good choice to preserve female fe ..read more
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Retraction Note: Mesenchymal stem/stromal cells as a valuable source for the treatment of immune-mediated disorders
BMC » Stem Cell Research & Therapy
by Alexander Markov, Lakshmi Thangavelu, Surendar Aravindhan, Angelina Olegovna Zekiy, Mostafa Jarahian, Max Stanley Chartrand, Yashwant Pathak, Faroogh Marofi, Somayeh Shamlou and Ali Hassanzadeh
2d ago
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Graft failure after allogeneic hematopoietic stem cell transplantation in pediatric patients with acute leukemia: autologous reconstitution or second transplant?
BMC » Stem Cell Research & Therapy
by Tahereh Rostami, Mohammad Reza Rostami, Amir Hossein Mirhosseini, Saeed Mohammadi, Mohsen Nikbakht, Hediyeh Alemi, Naghmeh Khavandgar, Soroush Rad, Ghasem Janbabai, Seied Asadollah Mousavi, Azadeh Kiumarsi and Amir Kasaeian
2d ago
Graft failure (GF) is a rare but serious complication after allogeneic hematopoietic stem cell transplantation (HSCT). Prevention of graft failure remains the most advisable approach as there is no clear recom ..read more
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Cell-specific extracellular vesicle-encapsulated exogenous GABA controls seizures in epilepsy
BMC » Stem Cell Research & Therapy
by Abhijna Ballal R, Shivakumar Reddy K, Divya Chandran, Sumukha Hegde, Raghavendra Upadhya, Praveen Kumar SE, Smita Shenoy, Vasudha Devi and Dinesh Upadhya
5d ago
Epilepsy affects ∼60 million people worldwide. Most antiseizure medications in the market act on voltage-gated sodium or calcium channels, indirectly modulating neurotransmitter GABA or glutamate levels or mul ..read more
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Transcriptomic profiling across human serotonin neuron differentiation via the FEV reporter system
BMC » Stem Cell Research & Therapy
by Yingqi Li, Jinjin Duan, You Li, Meihui Zhang, Jiaan Wu, Guanhao Wang, Shuanqing Li, Zhangsen Hu, Yi Qu, Yunhe Li, Xiran Hu, Fei Guo, Lining Cao and Jianfeng Lu
5d ago
The detailed transcriptomic profiles during human serotonin neuron (SN) differentiation remain elusive. The establishment of a reporter system based on SN terminal selector holds promise to produce highly-puri ..read more
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Treatment of COVID-19-associated ARDS with umbilical cord-derived mesenchymal stromal cells in the STROMA-CoV-2 multicenter randomized double-blind trial: long-term safety, respiratory function, and quality of life
BMC » Stem Cell Research & Therapy
by Alexandre Sitbon, Caroline Hauw-Berlemont, Miryam Mebarki, Nicholas Heming, Julien Mayaux, Jean-Luc Diehl, Alexandre Demoule, Djillali Annane, Clémence Marois, Sophie Demeret, Emmanuel Weiss, Guillaume Voiriot, Muriel Fartoukh, Jean‐Michel Constantin, Bruno Mégarbane, Gaëtan Plantefève…
5d ago
The STROMA-CoV-2 study was a French phase 2b, multicenter, double-blind, randomized, placebo-controlled clinical trial that did not identify a significant efficacy of umbilical cord-derived mesenchymal stromal ..read more
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Monoallelic KRAS (G13C) mutation triggers dysregulated expansion in induced pluripotent stem cell-derived hematopoietic progenitor cells
BMC » Stem Cell Research & Therapy
by Huan-Ting Lin, Masatoshi Takagi, Kenji Kubara, Kazuto Yamazaki, Fumiko Michikawa, Takashi Okumura, Takuya Naruto, Tomohiro Morio, Koji Miyazaki, Hideki Taniguchi and Makoto Otsu
1w ago
Although oncogenic RAS mutants are thought to exert mutagenic effects upon blood cells, it remains uncertain how a single oncogenic RAS impacts non-transformed multipotent hematopoietic stem or progenitor cells ..read more
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An integrated toolkit for human microglia functional genomics
BMC » Stem Cell Research & Therapy
by Imdadul Haq, Jason C. Ngo, Nainika Roy, Richard L. Pan, Nadiya Nawsheen, Rebecca Chiu, Ya Zhang, Masashi Fujita, Rajesh K. Soni, Xuebing Wu, David A. Bennett, Vilas Menon, Marta Olah and Falak Sher
2w ago
Microglia, the brain’s resident immune cells, play vital roles in brain development, and disorders like Alzheimer’s disease (AD). Human iPSC-derived microglia (iMG) provide a promising model to study these pro ..read more
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