Comedian/writer/actress Laura Kightlinger (@KingKightlinger) joins Matt, Jesse and Andy to talk about spontaneous human combustion, Bourbon Room comedy shows in Hollywood, the story behind Andy's various bands,  the Uranus story we don't want to cover, how one atom can change a parrot's color, blurb machine Peter Travers, peacock spiders, a blue whale that's been leaking oil for 26 years and a flu strain that we've basically beaten.  ..read more

Comedian/biomedical engineer Pallavi Gunalan (@PallaviGunalan) joins Matt, Jesse and Andy to talk about her path from science to comedy, working on open-source ventilators, the oldest living skydiver, the oldest surfer, growing human kidneys in pigs, the surprising intelligence of jellyfish and a misread of one of Newton's laws ..read more

Screenwriter James Lamont joins Matt, Jesse and Andy to talk about writing the upcoming Paddington in Peru, alcohol detox champion hornets, Shatner's double SPATS, memory not being confined to the brain, Jesse getting checked in on by local kids and Matt's oath to take up arms for the United States ..read more

Comedian Benny Blue (@bennyblueeyes) joins Jesse, Andy and Matt to talk about brat summer transitioning into the fall of civilization, Benny's new special Live From My Mother's Funeral, Benny and Andy's Blue Lake connection, Anarchist Cookbook adolescent shenanigans, why humans are the perfect size for speed, Matt and Andy's show with the 2022-iest name ever, the best mural ever painted and its painter, Norm MacDonald's sketch artist sketch, how an asteroid got ants into farming fungi, Jesse's love of 90-Day Fiancee, Matt's upcoming comedy shows and Andy's upcoming ska shows ..read more

Comedian and former Probably Science cohost Brooks Wheelan (@brookswheelan) joins Jesse and Andy to talk about his new special Alive In Alaska, Tony Hinchcliffe entering the election arena, cats beating babies at word association, Don't Wake Daddy, snake talk just for Brooks, the Teddy Roosevelt biography The River of Doubt, Chuck Klosterman's The Nineties, the ever-changing landscape of standup and Andy's upcoming gigs with Warsaw Poland Bros ..read more

Comedian Jeffrey Jay (@heyjeffreyjay) joins Matt, Jesse and Andy to discuss UnCertified Fresh, the Matt Walsh-iverse of awful movies, Earth gaining a second moon, the orbital path of that object, an octopus that punches fish to make them help it hunt and choceted EEG caps for cats ..read more

DJ Qualls (@TheOnlyDJQualls) and Kelly Blackheart (@kellyblackheart) of the Locked & Probably Loaded podcast join Matt and Jesse to talk about DJ's upcoming movie Carved, Nashville dive bars, the Ark Encounter, the Ig Nobel prize for butt-breathing, extreme aging, re-creating Mars in a lab and resurrecting the woolly mammoth ..read more

Comedian/actress/podcaster Helen Hong (@funnyhelenhong) joins Matt and Andy to talk about peeing in pools and reservoirs, male stripper shows, Helen's excellent quiz podcast Go Fact Yourself, pre-Darth Vader David Prowse PSAs, the dye in Doritos that can make mice transparent, a SpaceX rocket punching a hole in the ionosphere, mailing poo in a box and making pyrex invisible with vegetable oil ..read more

Comedian Kim McVicar (@KimMcVicar) joins Andy, Matt and Jesse to talk about famous hecklers, Kim's dancing background, musicals and their parodies, coin flips not being as 50/50 as you think, neanderthal early birds, Daylight Saving Time talk, holiday penile fractures and the crazy waves hitting the west coast right now ..read more

Brooks Wheelan (@brookswheelan) returns to the podcast to celebrate 500 episodes of Probably Science and talk about Probarbenheimer, the demise of Summer Country, a new venomous snake, a solar telescope array that cost half as much as White Chicks, unlocking car doors with tennis balls and creating weather forecasts with AI ..read more