Nature Reviews Molecular Cell Biology, Published online: 29 April 2024; doi:10.1038/s41580-024-00729-9 This article reviews the current landscape of targeted protein degradation approaches and how they have parallels in biological processes. The authors also outline the ongoing clinical exploration of novel degraders and provide some perspectives on the directions the field might take ..read more

Nature Reviews Molecular Cell Biology, Published online: 29 April 2024; doi:10.1038/s41580-024-00733-z During embryonic epithelial–mesenchymal transition, epithelial cells undergo substantial phenotypic changes and acquire migration capacity. This Review compares embryonic and adult non-cancer EMTs and discusses the role of EMTs in adult tissue repair and fibrosis, highlighting therapeutic opportunities to modulate EMT to reduce fibrosis and promote repair ..read more

Nature Reviews Molecular Cell Biology, Published online: 23 April 2024; doi:10.1038/s41580-024-00727-x The senescence-associated secretory phenotype (SASP) mediates the tissue effects of senescent cells. This Review discusses the composition, regulation and various biological implications of the SASP and its uses as a biomarker and a target of senomorphic drugs to treat cancer and other age-related conditions ..read more

Nature Reviews Molecular Cell Biology, Published online: 22 April 2024; doi:10.1038/s41580-024-00735-x Robert Parton and colleagues discuss novel evidence on the role of dynamin in caveolar endocytosis, which calls into question established models of dynamin-mediated fission ..read more

Nature Reviews Molecular Cell Biology, Published online: 12 April 2024; doi:10.1038/s41580-024-00736-w In the Journal Club, Fabrizio d’Adda di Fagagna remembers how the work of Judy Campisi changed our understanding of cellular senescence and its effect on physiology and ageing, shaping the future of this research field ..read more

Nature Reviews Molecular Cell Biology, Published online: 12 April 2024; doi:10.1038/s41580-024-00728-w The first evidence that the formation of protein complexes is linked to protein synthesis was already provided in the early 1960s ..read more

Nature Reviews Molecular Cell Biology, Published online: 10 April 2024; doi:10.1038/s41580-024-00719-x Tissues undergo changes in their mechanical and material properties through alterations in cytoskeleton organization, extracellular matrix adhesion and cell–cell connectivity. These mechanical state transitions orchestrate cell proliferation and movement and tissue growth during development, in adult tissue repair and in disease contexts ..read more

Nature Reviews Molecular Cell Biology, Published online: 09 April 2024; doi:10.1038/s41580-024-00734-y This study presents a new iPS cell-based model to study the mechanisms of tau propagation in 4R tauopathies ..read more

Nature Reviews Molecular Cell Biology, Published online: 08 April 2024; doi:10.1038/s41580-024-00716-0 Fibroblasts undergo transient activation into myofibroblasts to restore homeostasis to injured tissues. This Review explores the influence of mechanical cues and epigenetic modifications on (myo)fibroblast activation and memory and discusses potential therapeutic prevention of persistent myofibroblast activation in fibrosis ..read more

Nature Reviews Molecular Cell Biology, Published online: 08 April 2024; doi:10.1038/s41580-024-00732-0 The assembly of large protein–pigment photosystem supercomplexes relies on several assembly factors. Zhang et al. describe a novel assembly factor that evolved during the terrestrialization of land plants ..read more