PMID:  Molecules. 2024 Mar 28 ;29(7). Epub 2024 Mar 28. PMID: 38611801 Abstract Title:  Anti-Inflammatory Properties of the Citrus Flavonoid Diosmetin: An Updated Review of Experimental Models. Abstract:  Inflammation is an essential contributor to various human diseases. Diosmetin (3',5,7-trihydroxy-4'-methoxyflavone), a citrus flavonoid, can be used as an anti-inflammatory agent. All the information in this article was collected from various research papers from online scientific databases such as PubMed and Web of Science. These studies have demonstrated that diosmetin can sl ..read more

PMID:  Inflammopharmacology. 2024 Apr 25. Epub 2024 Apr 25. PMID: 38662182 Abstract Title:  Diosmetin attenuates fibromyalgia-like symptoms in a reserpine-induced model in mice. Abstract:  Fibromyalgia is a potentially disabling idiopathic disease characterized by widespread chronic pain associated with comorbidities such as fatigue, anxiety, and depression. Current therapeutic approaches present adverse effects that limit adherence to therapy. Diosmetin, an aglycone of the flavonoid glycoside diosmin found in citrus fruits and the leaves of Olea europaea L., has antinociceptive ..read more

PMID:  Heliyon. 2024 Apr 30 ;10(8):e29385. Epub 2024 Apr 16. PMID: 38665592 Abstract Title:  Impact of coconut kernel extract on carcinogen-induced skin cancer model: Oxidative stress, C-MYC proto-oncogene and tumor formation. Abstract:  This study aimed at analysing the effects of coconut (L.) kernel extract (CKE) on oxidative stress, C-MYC proto-oncogene, and tumour formation in a skin cancer model. Tumorigenesis was induced by dimethylbenz[a]anthracene (DMBA)/12--tetradecanoylphorbol-13-acetate (TPA). In vitro antioxidant activity of CKE was assessed using 2, 2-diphenyl-1-pic ..read more

PMID:  Phytomedicine. 2024 Apr ;126:155407. Epub 2024 Feb 2. PMID: 38340577 Abstract Title:  Tiliroside attenuates acute kidney injury by inhibiting ferroptosis through the disruption of NRF2-KEAP1 interaction. Abstract:  BACKGROUND: Ferroptosis, an iron-dependent process that regulates cell death. Emerging evidences suggest that ferroptosis induces acute kidney injury (AKI) progression, and inhibiting ferroptosis provides an effect strategy for AKI treatment. The disruption of the NRF2-KEAP1 protein to protein interaction (PPI) induces NRF2 activation, which provides a promisin ..read more

PMID:  J Agric Food Chem. 2024 Apr 11. Epub 2024 Apr 11. PMID: 38602402 Abstract Title:  Galangin Prevents Against Ethanol-Induced Intestinal Barrier Dysfunction and NLRP3 Inflammasome Activation via NF-κB/MAPK Signaling Pathways in Mice and Caco-2 Cells. Abstract:  The potential of natural phytochemicals in addressing ethanol-related public safety concerns has been garnering attention. Galangin, a potent flavonoid renowned for its antioxidative and anti-inflammatory characteristics, is derived from the galanga plant, and propolis is derived from bees. Here, we documented the ef ..read more

n/a PMID:  Transl Cancer Res. 2024 Jan 31 ;13(1):348-362. Epub 2024 Jan 12. PMID: 38410229 Abstract Title:  Sinensetin suppresses breast cancer cell progression via Wnt/β-catenin pathway inhibition. Abstract:  BACKGROUND: Although there are many treatments for breast cancer, such as surgery, radiotherapy, chemotherapy, estrogen receptor antagonists, immune checkpoint inhibitors and so on. However, safer and more effective therapeutic drugs for breast cancer are needed. Sinensetin, a safer therapeutic drugs, come from citrus species and medicinal plants used in traditional medici ..read more

PMID:  Drug Chem Toxicol. 2024 Apr 22:1-12. Epub 2024 Apr 22. PMID: 38647073 Abstract Title:  Naringenin mitigates cadmium-induced cell death, oxidative stress, mitochondrial dysfunction, and inflammation in KGN cells by regulating the expression of sirtuin-1. Abstract:  The objective of this study was to examine the potential protective role of naringenin against the harmful effects induced by cadmium in KGN cell line. Cell viability was evaluated by cell counting kit-8 assay. Caspase-3/-9 activities were determined by caspase-3/-9 activity assay kits, respectively. Intracellul ..read more

PMID:  Food Sci Nutr. 2023 Dec ;11(12):7523-7533. Epub 2023 Oct 8. PMID: 38107097 Abstract Title:  A narrative review on the role of hesperidin on metabolic parameters, liver enzymes, and inflammatory markers in nonalcoholic fatty liver disease. Abstract:  Insulin resistance, oxidative stress, hyperlipidemia, and inflammation play main roles in the development of nonalcoholic fatty liver disease (NAFLD). Some studies have reported that hesperidin can reduce hyperglycemia and hyperlipidemia by inhibiting inflammatory pathways. In the current study, our purpose was to evaluate whe ..read more

PMID:  Open Vet J. 2023 Dec ;13(12):1718-1728. Epub 2023 Dec 31. PMID: 38292716 Abstract Title:  The role of hesperidin as a cardioprotective strategy against doxorubicin-induced cardiotoxicity: The antioxidant, anti-inflammatory, antiapoptotic, and cytoprotective potentials. Abstract:  BACKGROUND: Doxorubicin (DOX), an anthracycline antibiotic, is a powerful chemotherapeutic agent effective against multiple types of cancer, particularly lung, breast, bladder and hematologic neoplasia (lymphomas and leukemia). However, its therapeutic usage is restricted by its known cardiotoxic ..read more

PMID:  J Med Food. 2024 Feb ;27(2):154-166. Epub 2024 Jan 30. PMID: 38294790 Abstract Title:  Hesperidin Protects Against High-Fat Diet-Induced Lipotoxicity in Rats by Inhibiting Pyroptosis. Abstract:  It is currently thought that excess fatty acid-induced lipotoxicity in hepatocytes is a critical initiator in the development of nonalcoholic fatty liver disease (NAFLD). Lipotoxicity can induce hepatocyte death; thus, reducing lipotoxicity is one of the most effective therapeutic methods to combat NAFLD. Abundant evidence has shown that hesperidin (HSP), a type of flavanone mainl ..read more