PMID:  Redox Rep. 2024 Dec ;29(1):2341470. Epub 2024 Apr 17. PMID: 38629504 Abstract Title:  Hesperidin activates Nrf2 to protect cochlear hair cells from cisplatin-induced damage. Abstract:  Cisplatin is widely employed in clinical oncology as an anticancer chemotherapy drug in clinical practice and is known for its severe ototoxic side effects. Prior research indicates that the accumulation of reactive oxygen species (ROS) plays a pivotal role in cisplatin's inner ear toxicity. Hesperidin is a flavanone glycoside extracted from citrus fruits that has anti-inflammatory and anti ..read more

PMID:  Behav Brain Res. 2024 Apr 4 ;466:114981. Epub 2024 Apr 4. PMID: 38580198 Abstract Title:  Berberine and hesperidin prevent the memory consolidation impairment induced by pentylenetetrazole in zebrafish. Abstract:  This study verified the effects of the natural compounds berberine and hesperidin on seizure development and cognitive impairment triggered by pentylenetetrazole (PTZ) in zebrafish. Adult animals were submitted to a training session in the inhibitory avoidance test and, after 10 minutes, they received an intraperitoneal injection of 25, 50, or 100 mg/kg berberin ..read more

PMID:  Open Vet J. 2024 Jan ;14(1):292-303. Epub 2024 Jan 31. PMID: 38633147 Abstract Title:  Ameliorative effects of berberine and selenium against paracetamol-induced hepatic toxicity in rats. Abstract:  BACKGROUND: Paracetamol (PCM) overdosing induces hepatotoxicity, which can result in death if the dose is high enough and the patients are not given N-acetyl cysteine. Berberine (BBR) has a variety of biological proprieties including anti-inflammatory and antioxidant activities.AIM: Assessment of the potential effect of BBR and selenium when used alone or together on the PCM-i ..read more

PMID:  J Appl Toxicol. 2024 Apr 19. Epub 2024 Apr 19. PMID: 38639436 Abstract Title:  Atorvastatin-induced intracerebral hemorrhage is inhibited by berberine in zebrafish. Abstract:  Intracerebral hemorrhage (ICH), for which there are currently no effective preventive or treatment methods, has a very high fatality rate. Statins, such as atorvastatin (ATV), are the first-line drugs for regulating blood lipids and treating hyperlipidemia-related cardiovascular diseases. However, ATV-associated ICH has been reported, although its incidence is rare. In this study, we aimed to invest ..read more

PMID:  Int Immunopharmacol. 2024 Apr 18 ;133:112036. Epub 2024 Apr 18. PMID: 38640713 Abstract Title:  Berberine alleviates neuroinflammation by downregulating NFkBκκNF/LCN2 pathway in sepsis-associated encephalopathy: Network pharmacology, bioinformatics, and experimental validation. Abstract:  BACKGROUND: Sepsis refers to a systemic inflammatory response caused by infection, involving multiple organs. Sepsis-associated encephalopathy (SAE), as one of the most common complications in patients with severe sepsis, refers to the diffuse brain dysfunction caused by sepsis without c ..read more

PMID:  Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2024 Apr ;32(2):639-642. PMID: 38660879 Abstract Title:  [Research Progress on the Role of Berberine in Hematologic Malignancies and Its Related Mechanisms --Review]. Abstract:  Berberine, a traditional Chinese medicine, is an isoquinoline alkaloid extracted from the rhizome of Coptis chinensis. It has anti-inflammatory and antidiarrheal effects and is commonly used in the treatment of infections and gastrointestinal diseases. In recent years, studies have found that berberine can play a wide range of anti-cancer effects in the treatmen ..read more

PMID:  Bioengineered. 2022 Apr ;13(4):10866-10874. PMID: 35473505 Abstract Title:  Arctiin elevates osteogenic differentiation of MC3T3-E1 cells by modulating cyclin D1. Abstract:  Osteoporosis is a systemic disorder of bone metabolism. This study aimed to investigate the impacts and possible mechanisms of Arctiin, a lignin isolated fromon MC3T3-E1 osteoblast differentiation. In this study, after treatment with different concentrations of Arctiin, reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and western blotting were used to estimate the expression of o ..read more

PMID:  Nutrients. 2022 Oct 25 ;14(21). Epub 2022 Oct 25. PMID: 36364745 Abstract Title:  High Cholesterol-Induced Bone Loss Is Attenuated by Arctiin via an Action in Osteoclasts. Abstract:  High cholesterol-induced bone loss is highly associated with oxidative stress, which leads to the generation of oxysterols, such as 7-ketocholesterol (7-KC). Here, we conducted in vivo and in vitro experiments to determine whether arctiin prevents high cholesterol diet-induced bone loss by decreasing oxidative stress. First, arctiin was orally administered to atherogenic diet (AD)-fed C57BL/6 ..read more

PMID:  Cureus. 2023 Sep ;15(9):e44987. Epub 2023 Sep 10. PMID: 37701157 Abstract Title:  Arctiin Inhibits Inflammation, Fibrosis, and Tumor Cell Migration in Rats With Ehrlich Solid Carcinoma. Abstract:  BACKGROUND AND OBJECTIVES: ESC or Ehrlich solid carcinoma is a type of tumor originating from a spontaneous mammary adenocarcinoma in mice. It is a highly aggressive and fast-growing carcinoma that can create a solid mass when inserted under the skin. Its solid, undifferentiated form makes it an ideal model for researching cancer biology, tumor immunology, and testing various an ..read more

PMID:  Int J Mol Med. 2023 Nov ;52(5). Epub 2023 Oct 6. PMID: 37800616 Abstract Title:  Arctiin attenuates iron overload‑induced osteoporosis by regulating the PI3K/Akt pathway. Abstract:  Iron overload is a prevalent pathological factor observed among elderly individuals and those with specific hematological disorders, and is frequently associated with an elevated incidence of osteoporosis. Although arctiin (ARC) has been shown to possess antioxidant properties and the ability to mitigate bone degeneration, its mechanism of action in the treatment of iron overload‑induced osteo ..read more